1
Q
What is the function of the anterolateral system?
A
- Pain and temperature
- Gross touch
- Light touch
2
Q
What is the definition of pain?
A
Unpleasant sensory or emotional experience associated with actual or potential tissue damage, or described in terms of such damage.
3
Q
What are the 2 duration classifications of the pain?
A
- Acute
- Chronic
4
Q
What causes nociceptive pain?
A
- Stimulation of peripheral nerve fibers or their receptors that only respond to stimuli approaching or exceeding harmful intensity
5
Q
What are the 3 modes of noxious stimulation to nociceptors?
A
- Thermal
- Mechanical
- Chemical
6
Q
What 3 terms are used to describe the perception of pain?
A
- Visceral
- Deep somatic
- Superficial somatic
7
Q
What type of pain is dull, aching, and poorly localized?
A
- Deep somatic
8
Q
What type of pain is sharp, well-defined, and clearly located?
A
- Superficial somatic
9
Q
What type of pain is diffuse, difficult to locate, and often referred?
A
- Visceral pain
10
Q
Why are somatic and visceral pain sometimes confused?
A
- They share afferent pathways
11
Q
What is neuropathic pain caused by?
A
- Damage or disease that affects any part of the nervous system involved in bodily feelings
12
Q
How is neuropathic pain typically described?
A
- Burning
- Tingling
- Electrical
- Stabbing
- Pins and Needles
- Funny bone
13
Q
What is phantom pain?
A
- Pain felt in a part of the body that the brain no longer receives signals from
14
Q
Phantom pain is a subtype of which type of pain?
A
- Neuropathic
15
Q
What is psychogenic pain caused by?
A
- Mental, emotional, or behavioral factors
16
Q
Why are psychogenic pain sufferers sometimes stigmatized?
A
- Medical professionals and general public think the pain isn’t real
17
Q
Is psychogenic pain real?
A
Yes
18
Q
What is referred pain?
A
- Pain occurs in an area away from the damaged/ pain site
19
Q
What are the 2 types of referred pain?
A
- Myofascial
- Sclerotomic & Dermatomic
20
Q
What is myofascial pain?
A
- Trigger points
- Nerve impulses bombard CNS and expresses as referred pain
21
Q
What is sclerotomic/ dermatomic pain?
A
Pain in the pattern of a spinal nerve root
22
Q
Where may the heart refer pain to?
A
- Upper chest
- Left shoulder
- Jaw
- Arm
23
Q
Where may the diaphragm refer pain to?
A
- Lateral tip of either shoulder
24
Q
Where may the gallbladder refer pain to?
A
- Right shoulder
- Inferior angle of right scapula
25
What referred pain may result from a ruptured spleen? What is this called?
- Pain on tip of shoulder
| - Kerr's sign
26
What may sclerotomic pain of L5 and S1 present as?
Lateral leg and foot pain
27
What is paresthesia?
- Abnormal spontaneous sensations such as burning, tinging or pins and needles
28
What is dyesthesia?
- Unpleasant sensation produced by a stimulus that is usually painless
29
What is anestheisa?
Loss of sensation
30
What is hypoesthesia?
Partial loss of touch and pressure sensations
31
What is hyperesthesia?
Increased sensitivity to touch and pressure sensations
32
What is analgesia?
Loss of pain and temperature sensations
33
What is hypoalgesia?
Partial loss of pain and temperature sensations
34
What is hyperalegsia?
- Increased sensitivity to pain sensations
35
What is myalgia?
Tenderness or pain in the muscles
36
What is malaise?
General discomfort/ uneasiness
37
What is causalsia?
Intense, severe burning pain
38
What is allodynia?
Non-painful stimuli evokes pain
39
What nerve fibers carry fast pain?
Myelinated a-delta
40
What nerve fibers carry slow pain?
Unmyelinated C fibers
41
What neuron transmits pain info to the spinal cord?
Nociceptive neurons
42
Which type of pain is more localized?
Fast
43
Is fast or slow pain aching, throbbing, burning?
Slow
44
What time frame is considered acute pain?
< 6 months
45
Which type of pain typically has more actual tissue damage?
- Acute
46
Which type of pain can have no actual damaging or threatening stimulus?
- Chronic
47
What time frame is considered chronic pain?
> 6 months
48
What type of nerve fibers is typically responsible for acute pain?
Group III
49
What are the 2 aspects of the pattern of pain?
- Frequency (firing rate of neuron)
| - Intensity (frequency of stimuli acting on neuron)
50
What types of pain does the specific/ anatomic theory of pain not hold true for?
Neurogenic
| Neuropathic
51
What are the 4 underlying aspects of the neuromatrix?
- Body self
- Sensory
- Affective
- Cognitive
52
What is the sensory aspect of the neuromatrix?
The actual stimulus
53
What is the affective aspect of the neuromatrix?
- Emotional or personality influence
54
What is the cognitive aspect of the neuronmatrix?
Frontal lobes remember pain
55
What role does the insular cortex play in pain perception?
- Distinguishes pain from other homeostratic emotions (itch, nausea_
56
What role does the anterior cingulate cortex play in pain perception?
- Motivation
57
What role does the sensory cortex play in pain perception?
Localizes pain
58
Do type IV or III fibers react more quickly to pain stimulus?
- IV
59
What is volume transmission?
Dumping of neurotransmitters
60
What do the primary afferents of pain synapse on?
- Tract cells
- Inhibitory interneurons that regulate ascending flow of nociceptive input
- Facilitory interneurons that regulate ascending flow of nociceptive input
- Interneurons that mediate local refelxes
61
What method of communicaiton is used by primary afferents of pain?
- Volume transmission
62
Which type of pain is more discriminitive? (fast or slow)
Fast
63
What laminae do fast pain fibers synapse on?
- Lamina 1 and 5 (marginal nuceleus)
64
What 2 areas do fast pain fibers synapse on in the higher centers?
- Lateral thalamus (VPL)
| - Post central gyrus of parietal cerebral cortex
65
On which laminae do most slow pain neurons synapse?
Laminae 2 and 5
66
What chemical mediators may cause a slow pain response?
- Histamine
- Prostaglandin
- Substance P
- Other inflammatory mediators
67
Which type of pain projects laterally? (fast or slow)
Fast pain
68
Which type of pain projects medially? (fast or slow)
Slow pain
69
Which type of pain has more interneurons? (fast or slow)
- Slow pain
70
Which type of pain deals with the affective components of pain? (fast or slow)
Slow pain
71
Which type of pain gives information regard perception of sharpness, intensity, location of pain? (fast or slow)
Fast pain
72
Where do the fast and slow pain fibers split during their ascent to higher centers?
- At the brain stem
73
What is the axon reflex (Why does the skin become red and flare up around the area of the injury)?
- Pain receptors transmit impulses in orthdromic and antidromic directions to neighboring skin, where free nerve endings release substance P binding to arteries, and causing dilation, and also binds to mast cells releasing histamine resulting in fluid accumulation
74
What is the triple response (in relation to inflammation)?
- Red line
- Flare
- Weal
in response to skin stretching
75
Which autonomic nervous system causes the redness of inflammation?
Sympathetic
76
What is peripheral sensitization of primary afferents?
- Nerves become inflamed and fire without reason or stimulus
77
What are the aspects of peripheral sensitization of primary afferents?
- Receptor sensitivity
- Membrane threshold lowered
- Ectopic firing (random firing)
78
Why is it so difficult to treat central sensitiization?
- There are so many causes
79
How may neuronal receptive fields be changed in central sensitization?
- Expanded so that more stimuli acts on one field
80
How can neuronal activity be altered in central sensitization?
- Increased response to noxious stimuli
81
How can the glia affect central sensitization?
- Release chemical mediators
82
How can interneurons affect central sensitization?
- Inhibit neurotrasmission
83
What is long-term potentiating?
- Stimulation of a cell over time increases it excitability/ and its duration of action
84
How can central sensitization affect membranes?
Lower thresholds
85
What is wind-up?
- Dorsal cells activated a lot, they'll fire more often
86
What is the origin of the lateral spinothalamic tract?
- Laminae I and V - VII in dorsal horn (nucleus proprius)
87
Do the fibers of the lateral spinothalamic tract cross?
Yes, at the level of the dorsal horn
88
What is the extent of the lateral spinothalamic tract?
- Throughout the cord
89
What does the lateral spinothalamic tract synapse on?
- Lateral thalamus
90
What is the function of the lateral spinothalamic tract?
- Concious pain and temperature
91
What is the origin of the anterior spinothalamic tract?
- Laminae III and V/ dorsal horn
92
Do the fibers of the anterior spinothalamic tract cross?
- Yes, at the level of the dorsal horn
93
What is the extent of the anterior spinothalamic tract?
- Throughout
94
What is the termination of the anterior spinothalamic tract?
- Medial thalamus
95
What is the function of anterior spinothalamic tract?
- Gross touch and pressure
| - Maybe pain
96
What is the origin of the spinotectal tract?
- Laminae I and V
97
Dot he fibers of the spinotectal tract cross?
Yes
98
What is the termination of the spinotectal tract?
- Tectum of midbrain
99
What is the function of the spinotectal tract?
Tectum: Reflexive responses to pain and temperature
| Locomotor center/ PAG: Aversise behavior and algesia
100
What is another name for the spinotectal tract?
Mesencephalic
101
What is the origin of the spinoreticular tract?
Laminae VI and VII
102
What is another name for the spinoreticular tract?
- Hypothalamic
| - Limbic
103
Do the fibers of spinoreticular tract cross?
Yes
104
What is the extent of the spinoreticular tract?
Throughout cord
105
What is the termination of the spinoreticular tract?
Reticular formation
106
What is the origin of the spinocervical tract?
- Laminae III and IV
107
Do the fibers of the spinocervical tract cross?
No
108
What is the extent of the spinocervical tract?
Throughout cord
109
What is the termination of the spinocervical tract?
Lateral cervical nucleus
110
What is the function of the spinocervical tract?
Possibly a secondary tract for Pain and temperature to cerebral levels
111
What is the function of the spinoreticular tract?
- Reflexive response and state of conciousness
112
What is the origin of the posterior synaptic dorsal column?
- Laminae X
113
Do the fibers of the posterior synaptic dorsal column cross?
No
114
What is the extent of the posterior synaptic dorsal column?
Throughout the cord
115
What is the termination of the posterior synaptic dorsal column?
The gracillis
116
What is the function of the posterior synaptic dorsal column?
Visceral pain
117
Where do the group III and IV afferents of the lateral spinothalamic tract enter the spinal cord? What is their pathway from entrance of the cord to their ascending pathway?
- Enter by the lateral division
- Go up or down 2 segments in Lissauers tract (dorsal-lateral fasciculus)
- Enter dorsal horn
- Synapse on projection cell
- Projection cell crosses over cordl through anterior white commisure
- Ascend as lateral spinothalamic tract
118
How are fibers added to the lateral spinothalamic tract as it ascends the spinal cord?
- From lateral to medial due to its contralateral - projection
- Arranged from lateral to medial:
- Sacral
- Lumbar
- Thoracic
- Cervical
119
Where do the two spinothalamic tracts split?
At the brain stem
120
Which spinothalamic tract is the phylogenetically older?
Anterior spinothalamic
121
Which spinothalamic tract has more synapses?
Anterior spinothalamic
122
Which tract constitutes the neo spinothalamic tract? Which tract consitutes the paleo spinothalamic tract?
Neo: Lateral spinothalamic
Paleo: Anterior spinothalamic
123
Where are phylogenetically newer structures located in the spinal cord?
On the lateral portion
124
What pathway does visceral pain take up the spinal cord?
Post-synaptic dorsal column
125
Why is meant by the "post-synaptic" in post-synaptic dorsal column?
A projection cell extends from the neuron in the dorsal horn to the pathway in the dorsal funniculus
126
What is the Melzak and Wall theory?
The gate theory.
Mechanoreceptor/ group II fibers synapse on the projection cell, inhibiting it
- There requires a stronger stimulus to activate pain projection fibers
127
What is the origin of descending modulatory sytems?
Periaqueductal gray
128
What nuclei are stimulated by the periaqueductal gray in the descending modulatory system?
- Lateral tegmental nucleus
| - Nucleus raphe magnus
129
What does the nucleus raphe magnus synapse on in the descending modulatory system?
- Inhibits projection neuron that travel to the dorsal horn
| - Excites endorphin interneuron that inhibits a projection cell to the dorsal horn and a-delta fiber
130
What does the lateral tegmental nucleus synapse on in the descending modulatory system?
- Excites an endorphin interneuron which inhibits projection neuron to dorsal horn and a-delta fiber
131
What neurotransmitter does the nucleus raphe magnus pathway use? What is the name of the pathway?
- Serotonin
132
What neurotransmitter does the lateral tegmental nucleus pathway use?
- Norepinephrine
133
What is the overall effect of the descending modulatory system?
If stimulated, it inhibits pain/ causes analgesia
134
What is the spinomesencephalic tract?
- Projections of the lateral spinothalamic tract to the periaqueductal gray
135
Review slides 24 - 27 possibly
24 - 27
Neuroscience
flashcards
Decks in class (33)
# Cards
-
Neurological Development107
-
The Skull18
-
Development Disorders20
-
The Spinal Cord38
-
Cytology110
-
Receptors77
-
Muscle Spindles56
-
Somatosensory System/ Ascending Tracts97
-
Autonomic Nervous System63
-
Nerve Fibers15
-
Descending Tracts134
-
Pain135
-
Pathology43
-
Spinal Cord Pathology66
-
Medulla Anatomy47
-
Pons Anatomy, Pathology87
-
Medulla Pathology36
-
Medullary Reflexes24
-
Trigeminal Nerve25
-
Vestibular System53
-
Cerebellum90
-
Reticular Formation35
-
Hearing78
-
Thalamus121
-
Hypothalamus95
-
Midbrain (OMG)26
-
Basal Ganglion75
-
Cortex Somatosensory51
-
Audition45
-
Motor Cortex46
-
Vision20
-
Olfactory System37
-
Limbic system25
