1
Q
1) Reasons of intra-corpuscular haemolytic anemia are all except:
a) changes of Er membranes
b) toxines in plasma
c) enzymopathy
d) hemoglobinopathy
A
b
2
Q
1) Most kommon kind of deficiency anemia is
a) B 12def
b) iron def
c) folic acid def
d) megaloblastic anemia
A
b
3
Q
1) B 12 deficiency anemia – all correct except
a) macrocytic
b) megaloblastic
c) hypochromic
d) pancytopenia
A
c
4
Q
1) Hypoplastic anemia – all correct except:
a) normochromic
b) microcytic
c) reticulocytes amount increased
d) EPO level in blood increased
A
c
5
Q
1) All is typical for the hemolytical anemia except
a) jaundice
b) hyperreticulocytosis
c) hemoglobinuria
d) bilirubinuria
e) urobilinuria
f) increase of free bilirubin in blood
A
d
6
Q
1) Erythrocytosis – all correct except
a) Er amount increased
b) Hb increased
c) Ht decreased
d) MCV normal
e) MCHC normal
A
c
7
Q
- Peripheral tolerance
a) inactivation of auto-reactive T or B cells
b) elimination of selfe-reactive T-cells in thymus
c) elimination of self-reactive B-cells in bone marrow
d) b+c
e) a+b+c
A
b
8
Q
- Anergy is state of
a) unresponsiveness to antibodies
b) unresponsiveness to antigens
c) unresponsiveness to T-cells
d) unresponsiveness to B-cells
A
b
9
Q
- Rheumatiod arthritis – all are correct, except
a) T-cell mediated
b) B-cell mediated
c) auto Ag – synovial joint Ag
d) a+b
e) a+b+c
A
b
10
Q
- Systemic lupus erythematosus
a) immune-complex disease
b) auto Ag – DNA
c) forms – arthritis, vasculitits, glomerulonephritis
d) a+b+c
e) a+b
f) a+c
A
d
11
Q
- Muliple sclerosis – all are correct, except
a) T-cell mediated
b) B-cell mediated
c) auto Ag – mielin basic proteins
d) brain invasion by CD4 T-cell
A
b
12
Q
- GC in treatment of autoimmune diseases are using for
a) inhibition of gene expresions
b) depletion of expanding lymphocytes population
c) blocking of co-stimulation
d) blocking of complement activation
e) blocking of cell adhesion
A
a
13
Q
- Antimetabolites in treatment of autoimmune diseases are using for
a) inhibition of gene expression
b) depletion of expamding lymphocytes population
c) blocking of co-stimulation
d) blocking of complement activation
e) blocking of cell adhesion
A
b
14
Q
- For neutralisation of cytokines are using
a) GC
b) antimetabolites
c) TNF-alpha inhibitors
d) IL-I inhibitors
e) a+b
f) c+d
A
f
15
Q
- Systemic autoimmune diseases are all except
a) rheumatoid arthritis
b) sclerodermia
c) autoimmune neutropenia
d) Sjogren syndrome
A
c
16
Q
- Estrogens
a) stimulate immune response
b) blocked immune response
c) not involved in immune response
d) blocked interferon – gamma production
A
a
17
Q
- In infants – normal level of thyroid hormones are necessary for (the main):
a. Development of CNS
b. Skeletal growth
c. Function of organ systems
d. Not necessary
A
a
18
Q
- T3 secretion is stimulated by:
a. Thyrotropin
b. T4
c. Thyrotropin releasing hormone
d. A + B
A
a
19
Q
- Forms of thyroid disease are:
a. Thyrotoxicosis
b. Goitre
c. Hypothyroidism
d. Thyroid nodule
e. A + B + C + D
f. A + B + C
A
e
20
Q
- All are correct for Graves disease, except:
a. Autoimmune
b. Exophthalmus
c. Enlarged thyroid
d. Increased serum TSH level
e. Increased metabolic rate
A
d
21
Q
- Congenital hypothyroidism is:
a. Hashimotos thyroiditis
b. Aplasia of TG
c. Lymphocytic thyroiditis
d. Hypothalamic disease
A
b
22
Q
- All are correct for Hashimotos thyroiditis:
a. Autoimmune
b. Decreased metabolic rate
c. Decreased TSH level
d. Decreased radioiodine uptake by TG
A
c
23
Q
- All are correct for medullary carcinoma of TG except:
a. 5-10% of all thyroid malignancies
b. 80% sporadic
c. Often – patients older than 50
d. Hypocalcitoninemia
A
d
24
Q
- Sex hormones are produced in cortex of adrenal gland in:
a. Zona glumerulosa
b. Zona fasciculate
c. Zona resticularis
d. A + B + C
e. A + B
f. A + C
A
c
25
1. Glucocorticoids activity in the body are regulated by processes in:
a. Liver
b. Kidneys,
c. Intestines
d. A + B
e. A + B + C
d
26
1. All are correct for Addissone disease, except:
a. Autoimmune
b. Decreased cortisol
c. Increased aldosterone
d. Increased ACTH
e. Primary
c
27
1. Ionized Ca (in % of total plasma Ca) is:
a. 30
b. 40
c. 50
d. 60
e. 70
c
28
1. PTH – all are correct except
a. Plasma Ca level increases – activates PTH synthesis
b. Plasma Ca level decreases – activates PTH synthesis
c. Increased osteoclastic activity
d. Increased Ca reabsorption in the kidneys
a
29
1. Calcitonin – all are correct except:
a. Decrease plasma Ca level
b. Increase plasma Ca level
c. Decrease bone resorbing
d. Decrease osteoclasts activity
b
30
1. GK
a. Decrease osteoblastic activity
b. Decrease Ca reabsorption in the kidneys
c. Induce osteoporosis
d. A + B
e. A + B + C
e
31
1. Hypercalcemia – total serum Ca level is:
a. >2.2
b. >2.4
c. >2.6
d. >2.8
a
32
1. Osteopenia – BMD is:
a. _ -2.5
d. -2.5 – -3.0
b
33
1. Primary osteoporosis:
a. Senile
b. Postemenopausal
c. Endocrine
d. A + B
e. A + B + C
d
34
1. Clinical classification of osteoporosis is:
a. Primary
b. Secondary
c. Idiopathic
d. A + B
e. A + B + C
e
35
1. Symptoms of hypoparathyroidism is:
a. Hypocalcinemia
b. Hypercalcinemia
c. Vit D deficiency
d. Neurologic manifestations
a
36
1. Cancer with bone metastases – changes in the blood:
a. Hypocalcinemia
b. Hypercalcinemia
c. Ca level normal
d. Decreased ionized Ca level
b
37
a. Testis secrete:
a. Testosterone
b. Dihydrotestosterone
c. Androstenodiole
d. Estradiol
e. Estrone
f. All
f
Pathological physiology
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