PARVO

Question 1

Surface feature of capsid
*5-fold
*3-fold
*2-fold

Answer 1

• 5-fold - hollow cylinder
• 3-fold - protrusion
• 2-fold - depressions

Question 2

Give two proteins of ORF 1 and where are they located?

Answer 2

3’ end of genome
NS1 & NS2

Question 3

Give two proteins of ORF 2 and where are they located?

Answer 3

5’ end of genome
VP1 & VP2

Question 4

(1) function of NS1

Answer 4

binds to DNA and required for viral DNA replication

Question 5

function of NS2

Answer 5

formed by splicing, regulates viral gene expression

Question 6

NS1 mediates arrest of cell in the ____ phase of cell cycle

Answer 6

G1 phase

Question 7

(2) receptor binding of parvo

Answer 7

1. Transferrin - CPV, FPV
2. Sialic acid - rodent parvo

Question 8

intermediates in parvo

Answer 8

ds DNA intermediates

Question 9

FPV targets ____ in kittens infected in perinatal stage

Answer 9

cerebellum (hypoplasia)

Question 10

lesions in Duck Parvovirus (2)

Answer 10

1. stunting
2. feathering is delayed

Question 11

lesions in Goose Parvovirus

Answer 11

necrotizing hepatitis

Question 12

Continuously dividing cells in older animals (3)

Answer 12

1. Hematopoietic precursors
2. Lymphocytes
3. Progenitor cells in intestinal mucosa