Path: Vasculitis

Question 1

Large vessel vasculitis

Answer 1

Giant cell arteritis

Takayasu arteritis

Question 2

Medium vessel vasculitis

Answer 2

Polyarteritis nodosa

Kawasaki disease

Question 3

Small vessel vasculitis

Answer 3

granulomatosis with polyangitis vasculitis type

Allergic granulomatosis with polyangitis

Microscopic polyangitis

Question 4

Large vessel Vasculitis pathogenesis

Answer 4

Immune mediated reaction causes damage to the vessel wall, impeding blood flow, turbulent flow leads to loss of perfusion (loss of pulse)

Question 5

What arteries are impacted in large vessel Vasculitis?

Answer 5

Elastic (example: aorta)

Question 6

What arteries are impacted in medium vessel Vasculitis?

Answer 6

Muscular arteries (renal arteries, coronary arteries)

Question 7

Medium vessel Vasculitis pathogenesis

Answer 7

Immune mediated reaction leads to flow being occluded and RBC’s being stuck

Question 8

What are the 3 downstream consequences in medium vessel Vasculitis?

Answer 8

Thrombosis, Infarction, Aneurysm

Question 9

What vessels are impacted in small vessel vasculitis?

Answer 9

Arterioles, capillaries

Question 10

Giant cell arteritis is most commonly found in whom? What age?

Answer 10

Females > 50 years old

Question 11

Giant cell arteritis is a ______________ disorder

Answer 11

Chronic granulomatous inflammatory

Question 12

What artery is most often impacted in giant cell arteritis?

Answer 12

Temporal artery

Question 13

Granulomatous vasculitis of medium and large-sized arteries that classically involves the AORTIC ARCH

Answer 13

Takayasu arteritis

Question 14

Takayasu arteritis is most commonly found in whom? What age?

Answer 14

Asian females < 40 years old

Question 15

How is upper extremity pulse in Takayasu arteritis?

Answer 15

Weak (pulseless disease)

Question 16

segmental thrombosing vasculitis of medium and small-sized arteries

Answer 16

Burger disease (thromboangiitis obliterans)

Question 17

In whom is Buerger disease most commonly found? And alongside what risk factor?

Answer 17

Males < 40 years old, Heavy tobacco smoking history

Question 18

Buerger disease may lead to what occurring?

Answer 18

Gangrene, autoamputation of digits

Question 19

How can Buerger disease be treated?

Answer 19

Smoking cessation

Question 20

Polyarteritis nodosa typically involves what vessels?

Answer 20

renal and visceral vessels

Question 21

What arteries are spared in polyarteritis nodosa?

Answer 21

pulmonary arteries

Question 22

Polyarteritis nodosa is most commonly found in whom?

Answer 22

Middle-aged males

Question 23

What is often found alongside those with polyarteritis nodosa?

Answer 23

Hepatitis B

Question 24

What aneursym appearance occurs in polyarteritis nodosa?

Answer 24

String of pearls aneursym appearance

Question 25

What clincial findings are present in polyarteritis nodosa?

Answer 25

HTN, neurologic dysfunction, renal damage, fever, weight loss

Question 26

In what aged children does Kawasaki Disease present?

Answer 26

Usually Asian children < 4 years old Heavy tobacco

Question 27

Symptoms of Kawasaki disease

Answer 27

CRASH F, Conjunctivitis, Rash, Adenopathy, Strawberry tongue, Hand-foot changes, Fever >/= 5 days

Question 28

What is a possible cardiac event that can occur in Kawasaki disease?

Answer 28

Myocardial infarction due to coronary arteritis

Question 29

ANCA-positive necrotizing granulomatosis vasculitis that involves the nasopharynx, lungs and kidneys

Answer 29

Granulomatosus Polyangiitis

Question 30

Classic presentation of granulomatosis polyangiitis is in whom?

Answer 30

Middle-aged males with sinusitis or nasopharyngeal ulceration

Question 31

Granulomatosis polyangiitis is positive for what antibodies?

Answer 31

C-ANCA (PR3- ANCA)

Question 32

What is the second most common systemic disorder associated with scleritis?

Answer 32

Granulomatosis polyangiitis

Question 33

How does orbital involvement in GAP manifest?

Answer 33

Proptosis, painful extra ocular muscle weakness

Question 34

Necrotizing granulomatous inflammation with eosinophils involving multiple organs, especially lungs and heart

Answer 34

Eosinophilic granulomatosus with polyangiitis (Churg-Strauss syndrome)

Question 35

What respiratory change is often present in Eosinophilic granulomatosus with polyangiitis?

Answer 35

Asthma

Question 36

What skin change occurs with Eosinophilic granulomatosus with polyangiitis?

Answer 36

Palpable cutaneous purpura

Question 37

How are IgE levels in Eosinophilic granulomatosus with polyangiitis?

Answer 37

Increased

Question 38

What antibodies are positive in Eosinophilic granulomatosus with polyangiitis?

Answer 38

P-ANCA (MPO-ANCA)

Question 39

Presentation similar to granulomatosis with polyangiitis but WITHOUT "nasopharyngeal involvement"

Answer 39

Microscopic polyangiitis

Question 40

Do granulomas form in microscopic polyangiiitis?

Answer 40

No

Question 41

Microscopic polyangiitis is positive for what antibodies?

Answer 41

P-ANCA (MPO-ANCA)