PATHOLOGY

Question 1

What is the mechanism unedrlying familial hypercholesterolaemia?

Answer 1

LDL Receptor mutation (Autosomal ddominant) whose severity depensd on receptor functionality

Question 2

LDL cholesterol 9-10 mmol/L is suggestive of what?

Answer 2

Heterzygote form => moderate to severe

Question 3

Management of Familial Hypercholesterolaemia?

Answer 3

1st line: High-dose Statin
2nd line:
3rd line: PCSK9 inhibitor: Evolocumab

Question 4

What complement deficiencies are present in SLE?

Answer 4

C1q + C1rs + C2 + C4

Question 5

C5 deficiency is associated with what condition?

Answer 5

Leiner’s disease present in infancy with darrhoea, seborrheic dermatitis

Question 6

C3 and C5-9 deficiencies are associated with what?

Answer 6

Neisseiria meningitidis (meningococcal meningitis)

Question 7

Most common non-atherotic angina cause?

Answer 7

Aortic regurgitation => imbalance between oxygen supply and demand
Other causes: thyrotoxicosis - AS - HCM - Anaemia

Question 8

What’s the predominant acid-base abnormality in ureteric diversion?

Answer 8

Metabolic acidosis