3 biochemical mechanisms of lead toxicity
sx in the neuro, GI, renal, and heme systems
hypersensitivity pneumonitis
actue vs chronic
lung histo
clin presentation and testing/labs
:vs - idiopathic pulmonary fibrosis
what are the four morphologic phases of this disease
D = lobar pneumonia
c= interstitial pulmonary fibrosis
e= chronic bronchitis
dx and etiology
diagnosis?
what is the histo picture showing
clinical presentation
lung= hilar adenopathy, fever, cough,
LAD= well formed, noncaseating granulomas
erythematous rash
uveitis
weight loss, night sweats, arthralgias
dx and etiology
EYE PATH
causes of
- cotton wool spots + dot-blot hemorrhages
- cotton wool spots with arteriolar narrowing and hard exudates
- acute monoocular vision loss with cherry red spot @ macule and retinal pallor
- insidious loss peripheral vision + enlarged retinal cup + pale optic disk
- subretinal drussen and abn pigment
xVHL –> CAs in which systems
wegeners= necrotizing vasulitis (nasal ulcerations, sinusitis, hemoptysis) + RPGN –> = Wegener/GPA/c-ANCA
=probably Abs against neutrophil proteinase 3
desribe tumors and sx in:
- tuberous sclerosis
- NF1
- NF2
- VHL
*
- tuberous sclerosis
- AD
- corticol tubers & subependymal hamartomas in brain
- cardiac rhabdomyoma
- facial angiofibroma
- ash-leaf patches on skin (lack pigment)
- renal angiomyolipoma (contain BVs, sm. M, +fat)
- NF1
- neurofibromas
- optic gliomas
- pigmented nodules of iris (Lisch Nodules)
- cutaenous hyperpigmented macules (cafe au lait spots)
- NF2
- bilateral acousting neuromas
- multiple meningiomas, gliomas, ependymomas
- VHL
- cerebellar hemangioblastomas
- retinal hemangiomas
- liver cysts
- bilateral RCC (clear cell type)
