Pemphigoid

Question 1

What population group usually get pemphigoid?

Answer 1

The elderly (60 years plus)

Question 2

Do the blister heal with or without scarring?

Answer 2

Without scarring

Question 3

What causes pemphigoid?

Answer 3

IgG autoantibodies against basement membrane

Question 4

What level does the blistering occur at?

Answer 4

The Subepidermal level.

• (Deeper than in pemiphus vulagris which is at the dermal-epidermal junction)
• Also why in pemphigoid they are tense whilst in PV they burst.

Question 5

How do you differentiate PV for pemphigoid?

Answer 5

Skin biopsy for routine and direct immunofluorescence