Oxidative
irreversible
G6P: G6PD: Ribulose5Phosphate
(-) NADPH
to make NADPH
Nonoxidative
reversible
Riboluse5Phosphate: trasketolases, B1, transaldolases: ribose5phosphate
to make nucleotides
Tissues for oxidative
adipose: FA synthesis
Gonads: steroid
liver: FA
RBC: gluathione reduction (reactive o2)
need NADPH only
oxidative = NADPH
nonoxidative to restart cycle
NADPH and ribose5P
oxidative
ribose 5P only
nonoxidative (high NADPH would inhibit)
NADPH and pyruvate
both
G6PD deficieincy (x linked)
no NADPH
hemolytic anemia: damage membrane bc Heinz bodies and reactive O2