ppt 3

Question 1

JC virus primarily causes which disease?

A. PML
B. Burkitt lymphoma
C. Glioblastoma
D. Bell palsy

Answer 1

J”C” - “c”erebrum relatedd
PML (Progressive multifocal leukoencephalopathy)

Question 2

BK virus commonly causes complications in:
A. Bone marrow transplant
B. Kidney transplant
C. Liver transplant
D. Lung transplant

Answer 2

B”K” virus
“K”idney transplant (→ hemorrhagic cystitis)

Question 3

Parvovirus B19 infects which precursor cells?

A. B lymphocytes
B. Erythroid precursors
C. Neutrophils
D. Fetal hepatocytes

Answer 3

“B”19 - “B”one marrow
Erythroid precursors

Question 4

Parvovirus B19 causes which childhood disease?

A. Roseola
B. Fifth disease
C. Chickenpox
D. Measles

Answer 4

Fifth disease (Erythema infectiosum, slapped-cheek rash)

imagine a small kid (smallest virus=parvovirus) “slapping” you on the face with all “5” fingers

Question 5

HSV-1 commonly establishes latency in which ganglion?

A. Genital ganglion
B. Trigeminal ganglion
C. Dorsal root ganglion
D. Facial nerve ganglion

Answer 5

Trigeminal nerve ganglion
HSV-1 mainly related to oral = trigeminal ganglion

HSV-2 mainly related to below = sacral ganglion

Question 6

Herpes labialis is the term for:

A. Genital herpes
B. Cold sores on lips
C. Oral thrush
D. Aphthous ulcers

Answer 6

Cold sores on lips

Question 7

What is the genome type of Parvovirus B19?

A. dsDNA
B. ssDNA
C. dsRNA
D. ssRNA

Answer 7

ssDNA

Question 8

Parvovirus B19 is unique because it is:

A. The smallest DNA virus
B. The largest DNA virus
C. The only enveloped DNA virus
D. The only segmented DNA virus

Answer 8

The smallest DNA virus

Question 9

Envelope status of Parvovirus B19:

A. Enveloped
B. Non-enveloped
C. Sometimes enveloped
D. Envelope depends on host cell

Answer 9

Non-enveloped

Question 10

Parvovirus B19 preferentially infects:
A. Lymphocytes
B. Erythroid precursors in bone marrow
C. Hepatocytes
D. Neurons

Answer 10

B. Erythroid precursors
(Mediated by P antigen (globoside))

Question 11

capsid of Parvovirus B19 is composed of:

A. Envelope glycoproteins
B. Two major structural proteins VP1 & VP2
C. Matrix proteins M1 and M2
D. Hemagglutinin

Answer 11

B. Two major structural proteins VP1 & VP2

Question 12

Giant pronormoblasts with “dog-ear” cytoplasmic projections are characteristic of infection by which virus?

A. Parvovirus B19
B. Epstein–Barr virus
C. Cytomegalovirus
D. Adenovirus

Answer 12

Parvovirus B19

Question 13

Giant pronormoblasts seen in Parvovirus B19 infection show which distinctive feature?

A. Cowdry A inclusions
B. Owl’s eye inclusions
C. Cytoplasmic blebs resembling dog-ear projections
D. Negri bodies

Answer 13

Cytoplasmic blebs resembling dog-ear projections

Question 14

Presence of giant pronormoblasts with dog-ear projections suggests which clinical condition?

A. Herpetic encephalitis
B. Aplastic crisis in sickle cell disease
C. Kaposi sarcoma
D. Hydrops fetalis from CMV

Answer 14

Aplastic crisis in sickle cell disease
(Parvovirus B19 infects erythroid precursors ➝ marrow suppression)

Question 15

HSV-1 oral lesions appear as:

A. Painful grouped vesicles on erythematous base
B. Painless ulcers
C. Purulent pustules
D. Necrotic plaques

Answer 15

A. Painful grouped vesicles on erythematous base

Question 16

Genital herpes is most commonly caused by:

A. HSV-1
B. HSV-2
C. CMV
D. VZV

Answer 16

HSV-2

Question 17

HSV-2 latency occurs in:

A. Trigeminal ganglion
B. Sacral ganglia
C. Dorsal root ganglia (thoracic)
D. Facial nerve

Answer 17

Sacral ganglia

Question 18

Eczema herpeticum occurs in patients with:

A. Atopic dermatitis
B. Diabetes
C. Burns
D. HIV

Answer 18

Atopic dermatitis
- caused by HSV-1 or HSV-2

Question 19

causative virus for eczema herpeticum is most commonly:

A. HSV-1
B. HSV-2
C. VZV
D. CMV

Answer 19

A. HSV-1 - more common
HSV-2 less common but yes

Question 20

Herpetic whitlow is seen commonly in:

A. Dentists
B. Surgeons
C. Wrestlers
D. Teachers

Answer 20

A. Dentists / health-care workers

Question 21

Herpetic whitlow affects mainly:

A. Lips
B. Fingers
C. Scalp
D. Eyelids

Answer 21

Fingers

Question 22

Herpes gladiatorum is typically seen in:

A. Dentists
B. Wrestlers
C. Sex workers
D. Gymnasts

Answer 22

Wrestlers

Question 23

Herpes gladiatorum affects which region?

A. Trunk
B. Feet
C. Face and neck
D. Genitals

Answer 23

Face and neck (+arms)

Question 24

Herpes esophagitis commonly shows:

A. Linear ulcers
B. Punched-out “volcano” ulcers
C. Cobblestone mucosa
D. Thick pseudomembrane

Answer 24

Punched-out “volcano” ulcers

Question 25

Herpes esophagitis is most common in: A. Healthy adults B. Infants C. Immunocompromised (AIDS, transplant) D. Pregnant women

Answer 25

Immunocompromised (AIDS, transplant)

Question 26

Primary infection with VZV causes: A. Shingles B. Chickenpox C. Herpes labialis D. Measles

Answer 26

Shingles

Question 27

VZV latency occurs in the: A. Trigeminal ganglion only B. Sacral ganglion C. Dorsal root ganglia D. CN VII

Answer 27

Dorsal root ganglia

Question 28

Characteristic feature of shingles: A. Bilateral rash B. Dermatomal painful vesicles C. Non-itchy petechiae D. Painless ulcers

Answer 28

Dermatomal painful vesicles

Question 29

Herpes zoster ophthalmicus affects: A. CN II B. CN V1 C. CN V2 D. CN VII

Answer 29

Ophthalmic division of trigeminal nerve (V1)

Question 30

Hutchinson’s sign indicates involvement of: A. Nasal mucosa B. Tip of the nose C. Ear canal D. Lips

Answer 30

B. Vesicle on tip of the nose indicates V1 involvement

Question 31

Herpes zoster oticus is due to involvement of: A. CN V B. CN VII C. CN IX D. CN II

Answer 31

B. Facial nerve (CN VII)

Question 32

Ramsay Hunt syndrome shows: A. Facial paralysis + vesicles in ear B. Vision loss + nasal vesicles C. Foot drop + thigh rash D. Hearing loss + trunk rash

Answer 32

A. Facial paralysis + vesicles in ear canal- ram ka dhyan karte samay na face pe expressions, na kaan me faltu ki aawaz

Question 33

Chickenpox rash classically shows: A. Same stage lesions B. Lesions in multiple stages (pleomorphic) C. Ulcerated plaques only D. Purpuric spots

Answer 33

B. Pleomorphic "dew-drop on a rose petal" lesions - Vijeta = VZV(chickepox) = rose jaisi vijeta ,parchicken khati hai

Question 34

Transmission of chickenpox is via: A. Fecal–oral B. Airborne + contact C. Blood-borne D. Sexual

Answer 34

Airborne + contact

Question 35

Congenital varicella syndrome is caused by infection during: A. 1st trimester B. 2nd trimester C. 3rd trimester only D. Labor

Answer 35

1st trimester (highestrisk)

Question 36

A classic feature of congenital varicella syndrome: A. Microcephaly B. Limb hypoplasia C. Cataracts D. Sensorineural deafness

Answer 36

Limb hypoplasia (plus cicatricial skin scarring) -vijetaka baccha

Question 37

Congenital varicella syndrome also includes: A. Hutchinson teeth B. Cicatricial skin lesions C. Blueberry muffin rash D. Strawberry tongue

Answer 37

Cicatricial (scarred) skin lesions - vijeta ka baccha

Question 38

VZV congenital infection mechanism involves: A. Transplacental viremia B. Breastmilk transmission C. Umbilical cord injury D. Intrapartum blood loss

Answer 38

Transplacental viral spread- vijeta ka baccha