What drug group does prednisolone belong to and what is its mechanism of action?
Belongs to a group called corticosteroids. It is an anti-inflammatory and immunosuppressant.
It binds to glucocorticoid receptors and inhibits the enzyme PLA2. This stops the production of prostaglandins and leukotrienes reducing inflammation and suppressing the immune response.
What are prednisolones indications for use?
Mainly used for asthma and croup exacerbations.
What are common side effects of prednisolone?
Increased appetite, indigestion, stomach irritation, mood swings, irritability, insomnia, restlessness.
What is absorption like for prednisolone?
Rapidly and almost completely absorbed primarily in the upper GI tract.
High oral bioavailability of 80-100%.
What is distribution like for prednisolone?
