Function of PRO
maintenance and regulation of bodily functions, growth, repair, and response to injury, can be converted to glucose or fat or burned as a last-resort energy source
Amino acids are precursors of …
proteins, neurotransmitters, nucleotides, melanin, thyroid hormone, histamine, peptides
Roles of PRO in blood:
plasma
hemoglobin
white
Tissue PRO
enzymes, structural, membrane receptors/carriers
Secretory PRO
digestive enzymes, human milk PRO, hormones, growth factor, apolipoproteins
How do PRO become amino acids?
they are denatured or the bond between them is cleaved by an enzyme
How can nutrition be used to treat some single-gene disorders?
by providing the necessary a.a. from dietary PRO
Nutritional genomics
examines interactions of genes and nutrients
Nutrigenics
examines how genes influence nutrients
nutrigenomics
examines how nutrients influence genes
Nutrient regulation of gene expression:
phytochemicals/signals activating/silencing metabolism activation/silencing PRO health
Nitrogen balance =
N intake - fecal N - urinary N
___ N balance: healthy for adults
positive: normal for ___
negative: signals a problem or dietary ___
zero
growth
deficiency
Deamination produces ___ and ___ acid. ___ is the process of the body making nonessential ___ from keto acids. Since ___ is toxic, it is combined with CO2 in the liver to make ___ which is excreted
ammonia/keto/transamination
a.a.
ammonia
urea
Kidney function:
glomerulus
needed/absorbed
bladder
PRO RDA:
AMDR:
Who needs above the RDA?
0.8g/kg/day (56g/day) for adults
10-35% of energy
those growing, athletes
sarcopenia
too little PRO
Excess PRO issues:
if consumption>rate of excretion:
N is excreted as urea (causes kidney and liver problems), carbon skeleton is converted to glucose or fat which causes weight gain, some a.a. are toxic if consumed in too high doses, risk of osteoporosis
Limiting amino acid
present in the lost amount relative to the body’s need
what happens to excess amino acids?
they are degraded
Digestible Indispensable Amino Acid Score
DIAAS: assesses PRO quality, exposed as % dietary requirement (considering ideal digestibility) for each a.a.
vegans/vegetarians should focus on ___ PRO
complementary