What is an advantage of using suppositories for drug delivery?
1. Can partially bypass the first-pass metabolism
2. Suitable for patients with diarrhea
3. Always results in rapid absorption
4. Easily swallowed
Can partially bypass the first-pass metabolism
Which of the following is a common shape of a rectal suppository?
Cylindrical
Bullet-shaped
Spherical
Disk-shaped
Bullet-shaped
Which physiological factor can influence drug absorption from rectal suppositories?
Stomach pH
Liver enzyme activity
Blood supply to the rectal area
Skin moisture content
Blood supply to the rectal area
What is a disadvantage of suppository administration?
Patients may find them uncomfortable or embarrassing to use
All suppositories must be refrigerated
They are quickly absorbed into the bloodstream
Suppositories have no first-pass effect
Patients may find them uncomfortable or embarrassing to use
Which of the following suppository bases is water-soluble?
Cocoa butter
Lanolin
White petrolatum
Glycerinated gelatin
Glycerinated gelatin
What is the typical size of a rectal suppository for adults?
3g
0.5g
1g
2g
2g
Which physiological factor can slow down drug absorption from a rectal suppository?
Low pH in the rectum
Elevated rectal temperature
High gastrointestinal motility
Low blood flow in the rectal mucosa
Low blood flow in the rectal mucosa
Which class of suppository base is more likely to melt at body temperature?
Cocoa butter
Glycerinated gelatin
Polyethylene glycol (PEG)
Lanolin
Cocoa butter
What is the primary function of excipients in suppositories?
To increase the bulk and stability of the suppository
To color the suppository
To delay the melting of the suppository
To enhance the taste of the suppository
To increase the bulk and stability of the suppository
Which of the following is NOT a disadvantage of using a rectal suppository?
May cause irritation to the rectal mucosa
Patient may find them inconvenient to use
Variability in drug absorption due to stool presence
Bypass first-pass metabolism
Bypass first-pass metabolism
Which physicochemical factor of a drug can influence its absorption from a suppository?
Molecular weight of the drug
Frequency of bowel movements
The patient’s weight
Rate of metabolism
Molecular weight of the drug
What is an advantage of glycerinated gelatin as a suppository base?
Suitable for hydrophobic drugs
Causes minimal irritation
Provides slow release of the drug
Melts at room temperature
Provides slow release of the drug
How do fatty bases such as cocoa butter affect drug release in suppositories?
They melt at body temperature, releasing the drug
They delay the absorption of water-soluble drugs
They absorb water to dissolve the drug
They react with the drug to form a gel
They melt at body temperature, releasing the drug
Which of the following suppository bases is suitable for both hydrophilic and lipophilic drugs?
Polyethylene glycol (PEG)
Glycerinated gelatin
Beeswax
Cocoa butter
Polyethylene glycol (PEG)
What is a key counseling point for patients using rectal suppositories?
Refrigerate the suppository before every use
Insert the suppository deeply into the rectum for better absorption
The suppository should be inserted after a bowel movement
Chew the suppository before insertion
The suppository should be inserted after a bowel movement
How does the presence of fecal matter affect the absorption of rectal suppositories?
It accelerates drug absorption
It inhibits or slows drug absorption
It increases blood flow in the rectum
It has no effect on drug absorption
It inhibits or slows drug absorption
What is a common excipient used to harden suppository bases?
Sodium lauryl sulfate
Magnesium stearate
Talc
Beeswax
Beeswax
Which USP requirement ensures that the correct dose is delivered in each suppository?
Hardness testing
Melting point test
Weight variation
Content uniformity
Content uniformity
What is an advantage of polyethylene glycol (PEG) bases for suppositories?
PEG bases melt at body temperature
PEG bases are ideal for rectal use only
PEG bases cause no irritation
PEG bases dissolve slowly, providing controlled drug release
PEG bases dissolve slowly, providing controlled drug release
Which type of drug would be best suited for administration via a rectal suppository?
A drug with extensive first-pass metabolism
A drug that needs immediate release in the stomach
A drug that is poorly absorbed through the skin
A drug that requires oral administration
A drug with extensive first-pass metabolism
Which of the following factors affects drug absorption in the rectum?
Renal function
Rectal blood flow
Stomach pH
Skin hydration
Rectal blood flow
Which type of suppository base is likely to cause rectal irritation?
Cocoa butter
White petrolatum
PEG
Lanolin
PEG
Which of the following USP tests ensures that suppositories melt at an appropriate rate?
Content uniformity
Melting range test
Weight variation
Disintegration test
Melting range test
Why are fatty bases such as cocoa butter used in suppositories?
They provide controlled drug release over time
They prevent rectal irritation
They dissolve in water quickly
They melt at body temperature and release the drug
They melt at body temperature and release the drug
