How many grams of glucose does the body use per hour (roughly)
13g/hr
There’s ~4g glucose in the blood at any given time (assuming normal glucose metabolism)
Glycogen stores in the liver and muscle
Liver 80-100g
Skeletal muscle 300-500g
How is insulin secreted in response to a meal?
Biphasic pattern; large burst in the first 30min and then smaller amounts over the next 1-2 hours
Counterregulatory hormones to insulin
Glucagon
Catecholamines
Glucocorticoids
Growth hormone
Number of genes that have been identified that can predispose someone to T2DM
> 70
Tests for LADA (Latent autoimmune diabetes in adults)
ICA and GAD65
%improvement in A1C from lifestyle
1 - 2%