RCC

Question 1

Age at diagnosis for which germline testing is indicated for RCC

Answer 1

Younger than 46

Question 2

RCC IHC

Answer 2

PAX2+
PAX8+
CK7 and CK20 negative

Question 3

Is there nodal dissection with nephrectomy?

Answer 3

No

Question 4

Indications for adjuvant pembro in RCC

Answer 4

• T2 with nuclear grade 4 or sarcomatoid differentiation
• T3a or higher
• node positive
• M1 NED

Question 5

Mutation seen in chromophobe

Answer 5

Folliculin (FLCN)

Question 6

Stage IV RCC

Answer 6

metastatic disease OR invasion beyond Gerota’s fascia

Question 7

Systemic therapy typically preferred for non clear cell

Answer 7

cabo

Question 8

First line for STage IV papillary RCC

Answer 8

cabo/nivo

Question 9

Frontline for metastatic renal medullary carcinoma

Answer 9

combination platinum-based cytotoxic chemotherapy,

Question 10

What drugs have shown a DFS benefit in the adjuvant setting for RCC

Answer 10

• pembro
  *Also sunitinib!