Regenerative Therapy

Question 1

Describe the process of repair following periodontal therapy

Answer 1

1. Fibrin clot fails to stick to root surface
2. Downgrowth of epithelial cells
3. Epithelial root attachment
4. Pocket closure BUT gingival recession

Question 2

Describe the critical events for regenerative in terms of the triad of tissue egineering

Answer 2

1. Fibrin clot adheres to sruface (scaffold)
2. Progenitor cells proliferate, migrate and differentiate (signalling molecules & cells)
3. Formation of new tissue - bone, cementum, PDL (cells)

Question 3

Why is space maintenance and clot protection important and how is it achieved?

Answer 3

• Allows new tissue to generate without downgrowth of epithelium to root
• Collagen barrier membrane

Question 4

What are the objectives of bone grafting?

Answer 4

• Space maintenance and clot protection
• Osteoconduction = scaffold
• Osteoinduction = promote osteoblast activity
• Osteogenesis = osteoblasts in graft

Question 5

Which bone graft is most ideal?

Answer 5

Autograft

Fulfills all objectives of bone grafting