Renal Osteodystrophy

Question 1

Describe the pathogenesis of renal osteodystrophy

Answer 1

1. Chronic kidney failure
2. Hyperphosphatemia drives down serum Ca2+
3. 1Alpha Hydroxylase activity decreases resulting in lower Vit D
4. Decreased Vit D results in decreased Ca2+ absorption from the gut

Question 2

What two conditions affect the bone in renal osteodystrophy

Answer 2

1. Osteitis fibrosa
2. Osteomalacia