Rosai Chapter 5 - Mandible and Maxilla

Question 1

Major extracellular components of the tooth (3)

Answer 1

“DEC”

• Dentin
• Enamel
• Cementum

Question 2

Major extracellular component of the tooth:

radially striated appearance caused by the presence of innumerable minute canals (the dentinal tubules) containing cytoplasmic processes from the odontoblasts

Answer 2

-Dentin

Question 3

Major extracellular component of the tooth:

Consists of thin rods or prisms that on cross section are separated by concentric lines (lines of Retzius)

Answer 3

-Enamel

Question 4

Major extracellular component of the tooth:

Very similar to bone in physicochemical characteristics and is indeed regarded as a special type of bone

Answer 4

-Cementum

Question 5

Nests of cells in odontogenic epithelium (2)

Answer 5

• rests of Serres

- rests of Malassez

Question 6

Nests of cells in odontogenic epithelium:

-located in alveolar mucosa

Answer 6

rests of Serres

Question 7

Nests of cells in odontogenic epithelium

-resulting from breakup of the dental lamina

Answer 7

rests of Serres

Question 8

Nests of cells in odontogenic epithelium

-embedded within the periodontium

Answer 8

-rests of Malassez

Question 9

other name of Pulse Granulomas (4):

Answer 9

• Hyaline ring-like structures
• Lentil granuloma
• Oral vegetable granuloma
• Giant cell hyaline angiopathy

Question 10

What disease entity?

Main microscopic finding:

-Acute suppurative inflammation and resorptive scalloping of margins of non-vital bone within a large portion of maxilla and mandible

Answer 10

-Acute and Subacute Osteomyelitis

Question 11

component of SAPHO Syndrome (5):

Answer 11

• Synovitis
• Acne
• Pustulosis
• Hyperostosis
• Osteitis

Question 12

True or False (re: SAPHO syndrome):

1. There is non-suppurative osteomyelitis of the jaw
2. Antibiotic therapy is NOT effective

Answer 12

1 & 2. True

Question 13

other name of Simple Bone Cyst (3):

Answer 13

• Traumatic cyst
• Solitary cyst
• Hemorrhagic cyst

Question 14

What histologic feature is common on these jaw lesions?

• Central giant cell lesion (granuloma)
• Cherubism
• Giant cell tumor (Osteoclastoma)
• Fibro-osseous lesions
• the bone lesion of Hyperparathyroidism (brown tumor)
• Hereditary hyperparathyroidism-jaw tumor syndrome
• Aneurysmal bone cyst

Answer 14

-Large numbers of Osteoclast-like multinucleated giant cells

Question 15

Most common lesion of the jaw that feature large numbers of Osteoclast-like multinucleated giant cells

Answer 15

-Central giant cell lesion (granuloma)

Question 16

other name of Central giant cell granuloma

Answer 16

Reparative giant cell granuloma

Question 17

other name of Ossifying fibroma (2):

Answer 17

• Cementifying fibroma

- Cemento-ossifying fibroma

Question 18

Types of Osseous dysplasia (3)

Answer 18

• Periapical
• Focal
• Florid

Question 19

Type of Osseous dysplasia:

-Found in middle-aged black women

Answer 19

-Periapical

Question 20

Type of Osseous dysplasia:

-Apex of a single tooth, usually a mandibular incisor

Answer 20

-Periapical

Question 21

Type of Osseous dysplasia:

-Multiple teeth in the posterior mandible

Answer 21

-Focal

Question 22

Type of Osseous dysplasia:

-Multiple jaw quadrants

Answer 22

-Florid

Question 23

Type of Osseous dysplasia:

-Symptomatic

Answer 23

-Florid

Question 24

Which entity?

Microscopically, the most typical feature:
-Presence of curvilinear trabecular (“ginger root” pattern) or irregularly-shaped cementum-like masses set within a vascular stroma

Answer 24

Osseous dysplasia

Question 25

Two major categories of epithelial cysts

Answer 25

- Odontogenic cysts | - Fissural (Non-odontogenic) cysts

Question 26

Category of Epithelial Cyst -arise from the odontogenic epithelium

Answer 26

-Odontogenic cyst

Question 27

Category of Epithelial Cyst -located within the jaw (rarely in the adjacent soft tissue)

Answer 27

-Odontogenic cyst

Question 28

Category of Epithelial Cyst -arise from epithelial inclusions within soft or body portions of the region that lack the embryologic and tooth-forming heritage of odontogenic epithelium

Answer 28

-Fissural (Non-odontogenic) cyst

Question 29

Category of Epithelial Cyst -along embryologic fissure lines

Answer 29

-Fissural (Non-odontogenic) cyst

Question 30

Category of Epithelial Cyst -outside of the jaw bones

Answer 30

-Fissural (Non-odontogenic) cyst

Question 31

Most frequent location of Adenomatoid Odontogenic Tumor

Answer 31

Anterior maxilla

Question 32

Other name of Adenomatoid Odontogenic Tumor

Answer 32

Adenoameloblastoma

Question 33

Other name of Calcifying Epithelial Odontogenic Tumor

Answer 33

Pindborg tumor

Question 34

Ameloblastic Fibroma vs. Ameloblastoma -Cellular myxoid connective tissue stroma - Present

Answer 34

Ameloblastic Fibroma

Question 35

Ameloblastic Fibroma vs. Ameloblastoma -Cellular myxoid connective tissue stroma - Absent

Answer 35

Ameloblastoma

Question 36

Most common odontogenic tumor

Answer 36

Odontoma

Question 37

Other name of Odontoameloblastoma (2):

Answer 37

- Ameloblastic Odontoma | - Odontoblastoma

Question 38

Odontoameloblastoma vs. Ameloblastoma -Dental hard tissues - Present

Answer 38

Odontoameloblastoma

Question 39

Odontoameloblastoma vs. Ameloblastoma -Dental hard tissues - Absent

Answer 39

Ameloblastoma

Question 40

Positive IHCs of Myxoma cells in Odontogenic Myxoma (2)

Answer 40

- Vimentin | - SMA

Question 41

Negative IHC of Myxoma cells in Odontogenic Myxoma

Answer 41

-S100

Question 42

Intramuscular myxoma vs. Odontogenic myxoma -Activating mutations in the GNAS1 gene - Present

Answer 42

Intramuscular myxoma

Question 43

Intramuscular myxoma vs. Odontogenic myxoma -Activating mutations in the GNAS1 gene - Absent

Answer 43

Odontogenic myxoma

Question 44

Most common of the epithelial odontogenic tumors

Answer 44

Ameloblastoma

Question 45

Two predominant patterns of ameloblastoma

Answer 45

- Follicular | - Plexiform

Question 46

Positive IHCs of Ameloblastoma (2)

Answer 46

- Cytokeratins (5, 14, 8, 18, and 19) | - Calretinin

Question 47

Cytokeratin IHC stain that is positive in Ameloblastoma cells in stellate reticulum-like areas (3)

Answer 47

- CK8 - CK18 - CK19

Question 48

Ameloblastoma vs. Keratocyst -Calretinin - Positive

Answer 48

Ameloblastoma

Question 49

Ameloblastoma vs. Keratocyst -Calretinin - Negative

Answer 49

Keratocyst

Question 50

Positive or Negative IHC of Granular cell Ameloblastoma: -Keratin

Answer 50

Positive

Question 51

Positive or Negative IHC of Granular cell Ameloblastoma: -CD68

Answer 51

Positive

Question 52

S100

Answer 52

Negative

Question 53

Type/s of Unicystic Ameloblastoma -Ameloblastous epithelium confine to the cyst lining

Answer 53

-Luminal and Intraluminal types

Question 54

Type/s of Unicystic Ameloblastoma -Ameloblastous epithelium extends into the underlying stroma

Answer 54

-Mural type

Question 55

Type/s of Unicystic Ameloblastoma Tx: Simple enucleation

Answer 55

-Luminal and Intraluminal types

Question 56

Type/s of Unicystic Ameloblastoma Tx: treated like conventional solid/multicystic ameloblastomas because they have recurrence risk

Answer 56

-Mural type

Question 57

Other name of ameloblastic fibrosarcoma (2)

Answer 57

- Odontogenic sarcoma | - Odontogenic fibrosarcoma

Question 58

Other name of Melanotic neuroectodermal tumor of infancy (2)

Answer 58

- Melanotic progonoma | - Retinal anlage tumor

Question 59

Most common location of Melanotic neuroectodermal tumor of infancy

Answer 59

Maxilla

Question 60

Positive IHCs of MNET of infancy -in the Small neuroblastic cells (4):

Answer 60

- NSE - CD57 - Synaptophysin - GFAP

Question 61

Positive IHCs of MNET of infancy -in the Epithelial cells (3)

Answer 61

- CK - HMB45 - Vimentin

Question 62

Most common primary malignant tumor of the jaw

Answer 62

Osteosarcoma

Question 63

Clue to the diagnosis of Tophaceous pseudogout (humoral Calcium Pyrophosphate Dehydrate Crystal Deposition Disease [CPDCDD])

Answer 63

-identification by polarized light of birefringent crystals associated with granulomatous reaction