SAMPLE RESULTS FOR SOME HEMOSTATIC TESTS

Question 1

• PT prolonged only
• APTT normal
• TT normal
• Platelet count normal indicates?

Answer 1

Factor VII deficiency

Question 2

• APTT prolonged only
• PT normal
• TT normal
• Platelet count normal indicates

Answer 2

• Deficiency of VIII IX XI XII or Prekallikrein or HMWK or von Willebrand’s disease or circulating anticoagulant (eg lupus)

Question 3

• PT prolonged
• APTT prolonged
• TT normal
• Platelet count normal indicates?

Answer 3

Vitamin K deficiency or oral anticoagulants or Factor V X or II deficiency

Question 4

• PT prolonged
• APTT prolonged
• TT prolonged
• Platelet count normal indicates?

Answer 4

1. Heparin (large amount)
2. liver disease
3. fibrinogen deficiency/disorder

Question 5

• PT normal
• APTT normal
• TT normal
• Platelet count low indicates?

Answer 5

Thrombocytopenia

Question 6

6. PT prolonged APTT prolonged TT prolonged Platelet count low indicates?

Answer 6

Disseminated intravascular coagulation (DIC)

Question 7

7. TT prolonged with PT and APTT normal suggests what class of problems?

Answer 7

Fibrinogen deficiency or dysfibrinogenemia or presence of thrombin inhibitors (eg heparin)

Question 8

8. PT normal APTT prolonged and bleeding with abnormal platelet function suggests?

Answer 8

von Willebrand’s disease (affects platelet function and aPTT variable)

Question 9

9. A pattern of prolonged PT with normal aPTT in an anticoagulated patient suggests what monitoring issue?

Answer 9

Warfarin effect or Vitamin K–dependent factor deficiency (especially VII)

Question 10

10. Simultaneous prolongation of PT APTT and TT with bleeding and low platelets most likely indicates what emergency condition?

Answer 10

Disseminated intravascular coagulation (DIC)

Question 11

• PT: N
• APTT: N
• TT: N
• PLT CT: N

Answer 11

1. present in aged serum, except factor: II
2. Disorder of platelet function
3. Factor XIII def.
4. Disorder of vascular hemostasis
5. Disorder of fibrinolysis

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