Cystitis (3)
1st 2 = MC in young women
- E coli (“adhesins / pili”, “motility”)
- Staph saprophyticus (“newly-sexually active woman”)
- Proteus sp (Urease ->↑urine pH -> “struvite stones”)
Urethritis (4)
1st 2 = same as for Cervicitis + PID
- Neisseria gonorrhoeae
- Chlamydia trachomatis (“glycogen inclusion bodies”)
- Ureaplasma urealyticum (Urease ->↑urine pH -> “struvite stones”)
- Trichomonas vaginalis (Flagellated Protozoa with “corkscrew motility”)
Pyelonephritis (2)
Path (2), Urine (2)?
- E coli
- Staph
PATH:
- Strictures
- Urinary stasis -> Colonization
URINE:
- Hematuria
- WBC CASTS
Cervicitis (3)
- N gonorrhoeae
- Chlamydia trachomatis
- Herpes (“intranuclear inclusions”)
Vulvovaginitis (3)
- Gardnerella vaginalis (anaerobes)
- Candida sp
- Trichomonas vaginalis
Bacterial Vaginosis
Gardnerella vaginalis (anaerobes)
Syphilis
Treponema pallidum
Chancroid
Haemophilus ducreyi
Lymphogranuloma venereum
Chlamydia trachomatis (serotypes L1-3)
Genital Herpes
HSV-2
HSV-1 less commonly
Trichomoniasis
Trichomonas vaginalis
Neisseria gonorrhoeae
Classification, Chars (4), STDs Seen In (5), Pres, DX, RX Against?
Gram - diplococci.
CHARS:
- IgA Protease
- Invasive (pilli)
- Antigenic variation
- Antiphagocytic
SEEN IN: Same as Chlamydia trachomatis
- Urethritis
- Cervicitis
- PID
- Epididymitis
- Prostatitis
PRES:
- Creamy purulent discharge
DX: Thayer-Martin agar
RX: Ceftriaxone
Chlamydia trachomatis
Chars (2), Pathogenesis, RX Against (2)?
CHARS:
- Obligate intracellular in epithelial cells
- Glycogen inclusion bodies in cytoplasm
PATH: Type IV h-s damage -> Scarring
RX:
- Tetracyclines (Doxycycline)
- Macrolides
Trichomonas vaginalis
Classification, Chars (2), STDs Seen In (2), RX Against?
Protozoa.
CHARS:
- Flagellated Protozoa
- Corkscrew motility
SEEN IN:
- Urethritis
- Vulvovaginitis (“strawberry cervix”)
RX: Metronidazole
HPV
Chars (2), Pathogenesis, Micro Finding (CLUE), Seen In (2)?
CHARS:
- dsDNA, naked, icosahedral
- “Intranuclear inclusion bodies”
PATH: HPV E6 + E7 proteins -> Inactivate cellular antioncogene.
FINDING: “Koilocytotic atypia”
SEEN IN:
- Condyloma Acuminatum (HPV-6 + -11)
- Cervical Ca
