Steroids

Question 1

name the carbons

Answer 1

Question 2

Answer 2

cortisol

Question 3

Answer 3

aldosterone

Question 4

Answer 4

progesterone

Question 5

Answer 5

testosterone

Question 6

Answer 6

17 beta estradiol

Question 7

progesterone

Answer 7

female menstrual cycle, pregnancy, embryogenesis

Question 8

17 beta estradiol

Answer 8

estrogen, female hormone

Question 9

testosterone

Answer 9

androgen, male hormone

Question 10

cortisol

Answer 10

glucocorticoid, anti-stress hormone, anti-inflammation

Question 11

aldosterone

Answer 11

mineralocorticoids, regulator Na uptake in kidney, raises blood volume and blood pressure

Question 12

17 alpha hydroxylase deficiency

Answer 12

adrenal hyperplasia (5%), overproduction mineralcorticoids, sex hormone deficiency, hyperaldosteronism

Question 13

21 hydroxylase deficiency

Answer 13

adrenal hyperplasia (95%), hirsutism, early epiphyseal closure, hypoaldosteronism

Question 14

aminoglutethimide (action/use)

Answer 14

inhibits aromatase and P450scc
used to block steroid production in some hormone-dependent tumors (breast, prostate)

Question 15

Answer 15

aminoglutethimide

Question 16

ketoconazole (action/use)

Answer 16

antifungal at lower concentrations by blocking the synthesis of estrogen, inhibits P450scc, 17 alpha-hydroxylase, 11 beta-hydroxylase
used for hyperglucocorticoid states (Cushing’s Syndrome)
may cause toxic side effects

Question 17

Answer 17

ketoconazole