Synaptogenesis

Question 0

Guidepost Cells

Answer 0

certain type of glia cells that adhere to growing Axon and direct it toward Target cell

direct some axons

Question 1

Synaptogenesis

Answer 1

developing junctions (synapses) between cells

it’s a competition/race: the ones that get there first monopolize the connections and the ones that get there later DIE

Question 2

After migration, Neurons grow _____ (branch for outgoing info) and later ______ (branches for incoming info)

Answer 2

axons

dendrites

Question 3

Axon must “find”appropriate ________ with which to communicate (i.e. on which to “synapse”)

Answer 3

Post-Synaptic Target cells

• growth cone
• some axons are directed by guidepost cells other depend on chemical trails

Question 4

Growth Cone

Answer 4

at end of elongating Axons

has many Filopodia that detect surrounding chemical gradients

Question 5

Chemical trails

Produced by?

Answer 5

produced by Glia cells or other migrating Neurons/Axons

Question 6

Neurotrophins

Answer 6

chemicals that attract/repel and PROMOTE SURVIVAL AND ACTIVITY of neurons

• e.g. Muscles/organs produce NGF (Nerve Growth Factor) that attract and promote survival of SNS Axons
• e.g. In CNS, BDNF (Brain Derived Neurotrophic Factor) promotes Axon survival and later Axonal branching