Systemic Sclerosis

Question 1

What are the features of limited cutaenous systemic sclerosis?

Answer 1

Raynauds
Scleroderma of face and distal limbs
Anti-centromere antibodies
CREST syndrome - calcinosis, raynauds, Esophogeal dysmotility, sclerodactylyl, telangiectasia

Question 2

What is the typical presentation of diffuse cutaneous systemic sclerosis?

Answer 2

Scleroderma of the trunk and proximal limbs
Can cause ILD and PAH
Rise of renal disease and HTN -> require captopril

Question 3

What antibodies are present in diffuse cutaneous systemic clerosis?

Answer 3

Anti-scl-70

Question 4

What are the features of scleroderma?

Answer 4

Tightening and fibrosis of skin
Manifest as plaques or linear

Question 5

What antibodies are seen in scleroderma?

Answer 5

ANA
RF
Anti-scl - inc diffuse cutaneous systemic sclerosis - high risk of ILD
Anti-centrometere - limited cutaenous systemic sclerosis