1
Q
what is tacrolimus
A
calcineurin inhibitor which inhibits lymphokines which then suppresses cell-mediated response
2
Q
tacrolimus prescription and dispensing requirements
A
by brand
3
Q
who should avoid tacrolimus
A
- women who are pregnant or breastfeeding
- those who have hypersensitivity to macrolides
4
Q
tacrolimus s/e
A
- HYPO/HYPER - tension
- HYPER - glycaemia, kalaemia, uricemia
- renal/liver impairment
- skin reactions
- visual disturbances
- blood dyscaria
- QT prolongation and cardiomyopathy in children
- nervous system disorder and peripheral neuropathy
5
Q
tacrolimus interactions
A
- grapefruit, pomegranate and pomelo juice = increase exposure
6
Q
tacrolimus monitoring
A
- BP
- ECG
- blood glucose
- LFT
- electrolytes
- CrCl
7
Q
what should be avoided with tacrolimus
A
- UV light and sunlight
- can affect driving and skilled performances
