TDM

Question 1

what to do when biological does not work?

Answer 1

1. switch to other drug that is less immunogenic
2. switch to other TNFi
3. assess drug trough level

Question 2

name 3 reasons why biological causes relapse

Answer 2

1. ADAb, anti-drug antibodies
2. injection of drug not at correct interval
3. increase in disease activity triggered by intercurrent infection

Question 3

name 3 functions of biologicals

Answer 3

1. cell elimination
2. receptor blocking
3. mediator neutralization

Question 4

name the 3 consequences when ADA occurs

Answer 4

1. rapid clearance of biologicals and loss of response
2. cytokine storm
3. hypersensitivity reaction

Question 5

what is the difference of the ELISA of Sanquin and Theradiag?

Answer 5

Sanquin; use of 2 antibodies (more specific)
Theradiag; directly plate bound

Question 6

name 3 factors bioavailability is depended on

Answer 6

1. distribution
2. degradation
3. neutralisation