Study of the physiological defenses by which the body recognizes itself from non self
Immunology
What are the immune functions
Cells of the immune system
Leukocytes
What are the types of leukocytes
Neutrophils (most common) Eosinophils basophils Monocytes Lymphocytes
Types of WBC’s
Granulocytes
Agranulocytes
What are the 3 types of granulocytes
First to appear at an infection that will phagocytize bacteria
Neutrophils
Two types of agranulocytes
Lymphocytes (25%
Monocytes 3-8%
How can immune defenses be classified?
Innate
Adaptive
Non-specific immune system
Innate
What defenses are included in innate immunity?
body surface
complement system
phagocytosis
Proteins that become activated when antibodies bond and coplement proteins promote destruction of the target cells
Complement system
Cells involved with Innate Immunity
Granulocytes
What is the sequence for innate immunity
Entry of microbe Vasodilation of infected area Increased capillary permeability Leukocyte invasion Destroy microbe Tissue repair
Process of Inflammation
Barrier break
damaged cells release chemicals that induce blood vessels to dilate
Clotting reactions seal off the infected region
WBC disinfect
Monocytes and macrophages release endogenous pyrogen in response to bacterial molecules
Fever
Induces hypothalamus to increase body temp
Fever
Specific immune system
adaptive
Specific Systematic- travel Has memory Late reponders Repond due to recognition of a specific antigen
Adaptive Immunity
Process through which body fights off antigens via formation of specific antibodies
Clonal selection theory
Determines which types of lymphocytes will need to be produced and in what quantities
Clonal Selection Theory
Steps for adaptive immunity
New antigen
Lymphocyte activated- triggers replication/clone formation to prohibit/prevent infection
2 types of cells produced in Lymphocyte activation
Effector
Memory
What are the classes of adaptive immunity
Antibody-mediated or humoral immunity
Cell-mediated immunity