thyroid conditions

Question 1

hypothyroidism vs hyperthyroidism

Answer 1

hypothyroidism

• aim is to replace thyroid hormone
• causes can be either acquired or defects in production

hyperthyroidism

• blocks thyroid hormone production or secretion
• happens a lot in cats

Question 2

meds used for thyroid replacement therapy (hypothyroidism)

Answer 2

L-thyroxine & thyroxine are usually the most used in dogs and cats

triiodothyroxine is recommended for dogs who can’t convert T4 to T3, must monitor when using the meds for the first 2 weeks

Question 3

antithyroid drugs

Answer 3

Thionamide drugs: thiamazole & carbimazole

• inactive until converted
• MOA is to inhibit thyroid peroxidase reactions and inhibit the conversion of T4 to T3

Question 4

general points

Answer 4

• good oral bioavailability

- adverse effects includes vomiting & anorexia