Thyroid disorder

Question 1

autoimmune in which body attack thyroid hormone.

Answer 1

HashimOtO (hypO)

Question 2

MOA of PTU

Answer 2

Inhibit TPO.

​​​At high doses inhibits conversion of peripheral conversion of T​4 ​to T​3​ by inhibiting 5-monodeiodinase.

Question 3

Drug of choice in pregnancy for hyperthyroidism. why

Answer 3

PTU.

Preferred in pregnancy because it has more protein binding and less absorption into placenta.

Question 4

t1/2 of PTU

Answer 4

only 2 hours

Question 5

Peak serum levels of PTU

Answer 5

seen after 1-hour

Question 6

Comparing PTU and methimazole, which is Secreted LESS in breast milk

Answer 6

PTU

Question 7

Methimazole and PTU which is a hypERthyroidism drugs comes under which structural class

Answer 7

THIONAMIDES