Thyroid facts

Question 1

TSH action

Answer 1

Acts on GPCR in thyroid increasing cAMP and PI3K
-increases thyroglobulin, peroxide, T3 and 4, blood flow

Question 2

hashimotos disease

Answer 2

autoimmune against TSH receptors
-low metabolic rate
-slow speech
-low heart rate
-cold
-waxy like skin

Question 3

Graves disease

Answer 3

autoimmune against TSH receptors
-high metabolism
-hot and sweating
-tremor
-tachycardia