TILDA Study

Question 1

Chronological Aging

Answer 1

Advancing in age in time

Question 2

Biological Aging

Answer 2

Increasing in health risks and increasing in chance of disease severity (increasing risk of hospilisation).

Question 3

Do biological and chronological aging always occur at the same rate

Answer 3

No. Studies have shown that people of the same chronological age can have different biological ages

Question 4

The Hallmarks of Aging

Answer 4

Genomic instability, telomere attrition, epigenetic alterations (DNA expression change), proteostasis loss, deregulated nutrient sensing, mytochondrial dysfunction, cellular senesence, stem cell exhaustion and altered intracellular communication

Question 5

How is altered intracellular communication accounted for

Answer 5

Clearance of senescent cells

Question 6

How is stem cell exhaustion accounted for

Answer 6

Mitohormetics (mild mitochondrial stress) and mitophagy (selective degradation of the mitochondria)

Question 7

First Systems to loose function as aging

Answer 7

reproductive, endocrine, cardiovascular and pulmonary. Aging has multisystem effects

Question 8

What causes biological aging

Answer 8

Molecular damage ( cumulative enviornmental exposure), defective repair, energy exhaustion and signal/noise reduction

Question 9

Effects of Phenotypic Aging

Answer 9

Body composition, energetics, homeostatic mechanisms and brain health

Question 10

Effects of health on functioning

Answer 10

cognitive, physical, mood and mental health

Question 11

What does TILDA Measure

Answer 11

health, social and economic parameters per participant. Eavluates quality of life for elderly (and improvements) finds a definition of ‘successful aging’

Question 12

Computer Assisted Personal Interview Data Collected

Answer 12

demographics, income, emplyment, health behaviours, health conditions, medications and health service use

Question 13

Self Completed Questionnaire Data Collected

Answer 13

social circumstances, quality of life, stress, diet, personality and sexual activity

Question 14

Health Assesment Data Collected

Answer 14

anthroporomety, visual function, cardiovascular function, cognitive function, musculoskeletal function and blood biomarkers. Samples taken: blood, hair, stool, saliva