Tranexamic acid (TXA)

Question 1

TXA Class

Answer 1

Antifibrinolytic

Question 2

TXA Action

Answer 2

Binds with receptor sites on plasmin to prevent plasmin from binding to and breaking down fibrin, thereby preventing the breakdown of blood clots

Question 3

TXA Indications

Answer 3

Significant bleeding secondary to trauma, prevention of excessive blood loss during surgery, reversal agent for anticoagulant medications, treatment for heavy menstrual periods

Question 4

TXA Contraindications

Answer 4

Hypersensitivity

Question 5

TXA Adult dose

Answer 5

1 g IVPB over 10 min, followed by 1 g IVPB over 8 hours

Question 6

TXA Side Effects

Answer 6

Headache, backache, sinus problems, ABD pain

Question 7

TXA Onset

Answer 7

Rapid

Question 8

TXA Duration

Answer 8

2 hours