What are the four Rs of radiobiology?
Repair of sublethal damage
Reassortment of cells within the cell cycle
Repopulation
Reoxygenation
Text: Radiobiology for the Radiologist
Radiosensitizing chemotherapeutics
Cisplatin
Carboplatin
Gemcitabine
5-FU
Dacarbazine
Lomustine
Doxorubicin
Methotrexate
Palladia
Early-responding tissues
Skin (epidermis)
Mucous Membranes
Brain
Eye (tear ducts and cornea)
GIT
Late-responding tissues
Brain
Spinal Cord
Nerves
Muscle
Bone
Eye (lens, retina)
Nose and sinuses
Kidneys
What would be the risk of using Metronidazole in a patient receiving radiation therapy?
Metro is a radiosensitizer, but shouldn’t cause any problems at the doses we use for diarrhea
Source: J Lyons