TRON

Question 1

4 Major Trials in TRON?

Answer 1

NASCIS: National Acute Spinal Cord Injury Study
CRASH: CS treatment in Acute Brain Injury
ONTT: Optic Neuritis Treatment Trial
IONTS: International ON Treatment Study

Question 2

ONTT trials arms?

Answer 2

1. Placebo
2. Oral Steroid 14 days
3. IVMP 3 days fb Oral Steroids 11 days

Question 3

ONTT trial result

Answer 3

All groups showed no significant diff in long term Visual outcome.

Oral asso with recurrence.

IVMP showed early visual recovery in first 2 mo.