Ulcerative colitis

Question 1

Ulcerative Colitis
* Signs & Symptoms

Answer 1

• Primary
• diarrhoea with blood
• hallmark of UC
• +/- mucus
• abdominal pain
• Secondary
• weight loss
• arthralgia
• anorexia
• nausea and vomiting
• Onset typically gradual
• followed by periods of spontaneous remission and subsequent
  relapses

Question 2

Ulcerative Colitis
* Diagnosis

Answer 2

• Dx via colonoscopy and biopsy
• Supportive Inx
• raised CRP and ESR
• elevated faecal lactoferrin and calprotectin
• increased IP
• active UC associated with ↑ IP (Salim and Soderholm, 2011)
• increased IP can also occur in remission
• 28.1% compared with 6.1% in healthy controls (P < 0.001)