functionally, the urogenital system can be divided into two entirely different components: the
urinary system and the genital system
Embryologically and anatomically, how ever, they are intimately interwoven. Both develop from a common mesodermal ridge called
intermediate mesoderm
is represented by 7 to 10 solid cell groups in the cervical region
These groups form vestigial excretory units, nephrotomes, that regress before more caudal ones are formed. By the end of the fourth week, all indications of the pronephric system have disappeared.
Pronephros
Three slightly overlapping kidney systems are formed in a cranial-to-caudal sequence during intrauterine life in humans:
pronephros, mesonephros, and metanephros
derived from intermediate mesoderm from upper thoracic to upper lumbar (L3) segments.
Early in the fourth week of develop ment, during regression of the pronephric system, what organ does it replace it with?
They lengthen rapidly, form an S-shaped loop, and acquire a tuft of capillaries that will form a glomerulus at their medial extremity
Mesonephros
An Mesonephros, around the glomerulus, the tubules form
Bowman’s capsule
glomerulus, the tubules form Bowman’s capsule, and together these form
renal corpuscle
Mesonephros Laterally, the tubule enters the longitudinal collecting duct known as the
mesonephric or wolffian duct
Mesonephros
Since the developing gonad is on its medial side, the ridge formed by both organs is known as the
urogenital ridge
Mesonephros
While caudal tubules are still differ
entiating, cranial tubules and glomeruli show
degenerative changes, and by the end of the sec
ond month, the majority have disappeared.
what happens to males and females
In the male, a few of the caudal tubules and the meso nephric duct persist and participate in formation of the genital system, but they disappear in the female.
The Definitive Kidney
permanent kidney
appears in the fi fth week.
Metanephros
Metanephros excretory units develop from
metanephric
mesoderm
kidney develops from two sources:
(1) metanephric mesoderm, which provides excretory units and (2) the ureteric bud, which gives rise to the collecting system.
At birth, the kidneys have a __________ appearance, but disappears during infancy as a result of further growth of the nephrons, although there is no increase in their number.
lobulated