1
Q
What is tissue tropism?
A
Tissue specific –> more likely to infect certain tissues and not others
2
Q
What are the factors influencing tissue tropism? (4)
A
- Access to tissue for replication
- Required receptors for binding/entry
- Expression of host gene for viral production and future infection
- Activity of host defense
3
Q
Compare the method of viral transmission in local infection and systemic disease
A
- Local infection: Shedding from initial infection site
2. Systemic disease: Shedding from multiple, distant sites
4
Q
What factors influence the means of viral transmission?
A
- Site of virus replication/release
2. Stability of virus particle
5
Q
Compare the method of viral transmission for enveloped and naked viruses
A
- Enveloped virus: fragile and sensitive to environment
* Close contact transmission - Naked virus: sustain environmental stress
* transmitted via virus-associated object
* through respiratory or fecal/oral route
6
Q
What are the environmental stresses affecting viral transmission? (3)
A
- pH
- temperature
- detergent
7
Q
List 4 host factors in susceptibility to viral disease.
A
- Appropriate receptors for virus entry
- Host age
- Genetic background
- Immune status
8
Q
Mechanism of immune-mediated viral infection
A
- Antibody mediated (immune complex)
- Cell mediated (rash, fever, malaise)
- Autoimmune (cross-reactivity)
- Transient immune modulation (immune suppression)
9
Q
Compare acute local and acute systemic infection
A
Check Anki
