efficacy
the power to produce an effect
quiescence
inactivity or dormancy
implore
to make an earnest request to (beg) OR to say something as a request in a sincere or urgent manner
exacerbate
to make more violent, bitter, or severe
empirical
originating in or based on observation or experience/can be verified based on observation
fractious
tending to be troublesome, unruly OR quarrelsome and irritable