Zofran (Ondansetron)

Question 1

Pharm and Action

Answer 1

Selective antagonist of a specific type of seratonin receptor located in the CNS at the chemoreceptor trigger zone and in the peripheral nervous system on nerve terminals of the vagus nerve; Drug blocking action may occur at both sides

Question 2

Indications

Answer 2

Nausea and Vomiting

Question 3

Contraindications

Answer 3

Hypersensitivity; Caution in patients with hepatic impairement

Question 4

Administration

Answer 4

Adult 4mg IV over 2-5 minutes; Pediatric over 40 kg 4mg, under 40 kg 0.1 mg/kg

Question 5

Side Effects and Special Notes

Answer 5

Headache, malaise, fatigue, dizziness, fever, sedation; Extrapyramidal symptoms, have Benadryl available; Pregnancy risk category B

Question 6

Class

Answer 6

A