118 Microcirculation

Question 1

Circulation methods for:

Gas Exchange

Water Soluble Solvents

Macromolecular Transport

Answer 1

Gas: through tissue, diffuses down gradient

Water solvents: tight junctions

Macro: through differeent capillaries (fenestrations, gaps, transcytosis)

Question 2

van’t Hoff equation

Answer 2

• Reflection Coefficient:
  
  • 0 : Perfectly permeable
  • 1 : Perfectly impermeable
• Good approximation:
  
  • Only proteins have a reflection coefficient of 1

Question 3

Starling equation: for capillary flow

Answer 3

Question 4

How does net filtration pressure change along the capillary

Answer 4

Question 5

Lymphatic circulation

Answer 5

parallel circulation

• Microvalves
• 2-4 L flow / day
• Drains excess fluid from interstitium (net loss of fluid from capillary to interstitum)

Question 6

Mechanisms for Control of Regional Blood Flow

Answer 6

Systemic:

• oNeural Mechanisms
• oHormonal Mechanisms

Local:

• oMyogenic Mechanisms
• oMetabolic Mechanisms
• oEndothelial Mechanisms

Question 7

Sympathetic Regulation of Blood Flow

Answer 7

Question 8

Histimine Regulation of Blood Flow

Answer 8

Question 9

Myogenic Regulation of Blood Flow

Answer 9

Question 10

Metabolic Regulation of Blood Flow

Answer 10

Question 11

Epithelial Regulation: Nitric Oxide

Blood Flow

Answer 11

Question 12

Epithelial Regulation: Endothelin

Blood Flow

Answer 12

Question 13

Active vs Reactive Hyperemia

Answer 13

Question 14

Coronary Circulation

Question 15

Cerebral Circulation

Answer 15

Question 16

Pulmonary circulation

Answer 16

Question 17

Skeletal Muscle Circulation

Answer 17

Question 18

Skeletal Muscle: Muscle Pump

Answer 18