2.6

Question 1

what type of cell involved in cell-mediated immunity produces cytokines and activate and recruit other cells

Answer 1

CD4 helper T cells

Question 2

what type of cell involved in cell-mediated immunity kills infected cells

Answer 2

CD8 cytotoxic T cells

Question 3

TCRs expressed on T cell clones can only recognize ___

Answer 3

one peptide / MHC complex

Question 4

T/F several peptides can be presented by different MHC I and MHC II molecules on the surface of the same DC

Answer 4

true

Question 5

what patrols LN in search of antigens with the perfect fit

Answer 5

T cells

Question 6

what does Th1 make and activate

Answer 6

• IFN gamma
• macrophages

Question 7

what does Th2 make and activate

Answer 7

• IL4, IL5, & IL13
• eosinophils

Question 8

what does Th17 make and activate

Answer 8

• IL17 & IL22
• neutrophils

Question 9

what determines the fate of naive T cells

Answer 9

cytokines produced by DC or other innate cells

Question 10

what is involved in the activation of macrophages by Th1 cells

Answer 10

CD40-CD40L & IFN gamma - IFN gammaR

Question 11

what do macrophages produce & upregulate

Answer 11

• cytokines
• MHC, costimulatory molecules, & microbicidal activities

Question 12

what induces B cells to produce IgE

Answer 12

IL-4

Question 13

what induces eosinophil activation and mediates worm elimination

Answer 13

IL-5

Question 14

what induces monocytes to become M2 macrophages and peristalsis of the gut

Answer 14

• IL-4 & IL-13

Question 15

what are M1 macrophages involved in

Answer 15

killing & inflammation

Question 16

what are M2 macrophages involved in

Answer 16

tissue repair and inhibition of inflammation

Question 17

what produces IL-17 & IL-22

Answer 17

Th17

Question 18

what induces antimicrobial peptide production by epithelial cells

Answer 18

IL-17 & IL-22

Question 19

what mediates recruitment of neutrophils via induction of cytokines / chemokines production from other cells

Answer 19

IL-17

Question 20

what mediates production of Ig by B cells

Answer 20

IL-21

Question 21

what is important for extracellular microbes

Answer 21

Th17

Question 22

what are released from granules and mediate killing

Answer 22

• perforin
• granzyme

Question 23

what cells activate macrophages to lyse intravesicular microbes

Answer 23

Th1

Question 24

what kills infected cells with help from Th1 cells

Answer 24

CD8

Question 25

which statement concerning Thelper cells is correct? a - Th1 cells make IL-4 and promote neutrophil activation b - Th1 cells make IL-17 and induce macrophage activation c - Th1 cells make IFN gamma and mediate eradication of intracellular bacteria d - Th2 cells make IL-4 mediate eradication of extracellular bacteria e - Th2 cells make IL-5 and inhibit worm killing by eosinophils

Answer 25

c - Th1 cells make IFN gamma and mediate eradication of intracellular bacteria

Question 26

what is the function of Th17 cells in response to infection? a - Th17 cells kill cells infected with intracellular microbes b - Th17 cells trigger antimicrobial peptides for clearance of intracellular bacteria c - Th17 cells help recruit neutrophils to the mucosa for clearance of extracellular microbes d - Th17 cells lead to mast cell degranulation for clearance of fungus e - Th17 cells make IL-5 and trigger worm killing by eosinophils

Answer 26

c - Th17 cells help recruit neutrophils to the mucosa for clearance of extracellular microbes

Question 27

how do activated cytotoxic T cells (CTL) kill cells infected with an intracellular microbe? a - CTL are activated with help from macrophage to generate MAC which lyse infected cells b - CTL are activated by DC and receive help from Thelper cells to produce perforin and granzyme which lyse infected cells c - CTL are activated by DC and Th1 cells to produce ROS which induce apoptosis of the infected cells d - CTL are only activated by B cells to produce perforin and granzyme that lyse infected cells e - CTL produce nitric oxide that kill infected cells

Answer 27

b - CTL are activated by DC and receive help from Thelper cells to produce perforin and granzyme which lyse infected cells

Question 28

match the following terms: 1 - Th17 2 - Th2 3 - Th1 a - IL-4 b - IFN gamma c - IL-17

Answer 28

1 - c 2 - a 3 - b

Question 29

cytokines produced by DC and other innate cells determine the date of naive T cells and the cytokine they will produce. What cytokines accurately induce Th cell differentiation? a - IFN gamma induces Th2 b - IL-12 induces Th17 c - IL-6 induces Th1 d - IL-5 induceTh17 e - IL-4 induces Th2

Answer 29

e - IL-4 induces Th2