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Question 1

1. Which one of the following best describes a physicochemical property of parvoviruses?
   (A) Envelopedvirusparticle.
   (B) Single-stranded DNA genome.
   (C) Infectivity is inactivated by ether treatment.
   (D) Virion exhibits helical symmetry.
   (E) Virion is about the same size as herpesviruses.

Answer 1

b

Question 2

2. An 8-year-old child recently had erythema infectiosum. Her 33-year-old mother subsequently developed arthralgia followed by painful arthritis with swelling in the small joints of both hands. In addition to the apparent tropism for joints, human parvovirus B19 is highly tropic for which cell type?
(A) CD4 T lymphocytes
(B) Renal tubule cells
(C) Erythroid cells
(D) Glial cells
(E) Peyer patches

Answer 2

c

Question 3

3. The 8-year-old child in Question 2 had an illness with more than one phase. Which symptoms coincide with the second phase of the illness?
(A) Sore throat
(B) Skin rash
(C) Headache
(D) Diarrhea
(E) Cough

Answer 3

b

Question 4

4. A 42-year-old man with HIV/AIDS presented with aplastic ane- mia. Using PCR, parvovirus B19 was detected in his serum. The patient presumably acquired his parvovirus B19 infection from another person. The most likely route of transmission is
   (A) By contact with respiratory secretions or droplets
   (B) By contact with a skin rash
   (C) Through sexual activity
   (D) Through a recent blood transfusion

Answer 4

a

Question 5

5. Which one of the following is a disease in which the role of par- vovirus B19 has not been established?
(A) Erythema infectiosum (fifth disease)
(B) Transient aplastic crisis
(C) Hydrops fetalis
(D) Fulminant hepatitis

Answer 5

d

Question 6

human parvovirus B19?
(A) Stimulates resting cells to proliferate
(B) Uses blood group antigen P as cellular receptor
(C) Readily establishes persistent infections
(D) Entire replication cycle occurs in cytoplasm
(E) Production of infectious progeny requires the presence of a helper virus

Answer 6

b

Question 7

7. Which one of the following statements is most accurate con- cerning human infections by parvovirus B19?
   (A) Parvovirus B19 is transmitted readily by sexual intercourse.
   (B) Patients with disseminated disease caused by parvovirus
   B19 should be treated with acyclovir.
   (C) Parvovirus B19 does not cause any human disease.
   (D) There is no vaccine for human parvovirus.

Answer 7

d

Question 8

8. Human bocavirus is a newly discovered parvovirus. It has been detected most frequently in which type of sample?
(A) Urine
(B) Cord blood
(C) Respiratory secretions
(D) Fetalliver
(E) Bone marrow

Answer 8

c

Question 9

9. Which of the following is available as a treatment or preventive for parvovirus B19 infections?
   (A) Commercial immunoglobulin
   (B) Vaccine containing recombinant VP2 viral antigen (C) Bone marrow transplantation
   (D) Antiviral drug that blocks virus–receptor interaction

Answer 9

a

Question 10

10. Human erythroviruses and bocaviruses share the following properties except for which one?
(A) Small, nonenveloped virus particles
(B) Difficult to culture
(C) Cause anemia
(D) Global distribution
(E) No vaccine exists

Answer 10

c