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Question 1

1. What adenovirus protein or proteins regulate early transcrip- tion of the viral genes and modulate the cell cycle?
(A) Fiber
(B) Hexon
(C) Penton
(D) Terminal protein
(E) E1 region protein
(F) Cysteine proteinase
(G) E3 region protein

Answer 1

e

Question 2

2. What adenovirus protein serves as primer for initiation of viral DNA synthesis?
   (A) Fiber
   (B) Hexon
   (C) Penton
   (D) Terminal protein (E) E1 region protein (F) Cysteine proteinase (G) E3 region protein

Answer 2

d

Question 3

3. Whatadenovirusproteincomprisesthemajorityofcapsomeres making up the virus capsid?
(A) Fiber
(B) Hexon
(C) Penton
(D) Terminal protein
(E) E1 region protein
(F) Cysteine proteinase
(G) E3 region protein

Answer 3

b

Question 4

4. A 3-month-old infant had watery diarrhea and fever for 10 days. Rotavirus or adenovirus type 40 or 41 are the suspected agents. What type of specimen would be most appropriate for detection of adenovirus type 40 or 41 infection in this patient?
(A) Blood
(B) Urine
(C) Conjunctival swab (D) Stool
(E) Throat swab
(F) Cerebrospinal fluid

Answer 4

d

Question 5

5. Which of the following human diseases has not been associated with adenoviruses?
   (A) Cancer
   (B) Common colds
   (C) Acute respiratory diseases (D) Keratoconjunctivitis
   (E) Gastroenteritis
   (F) Hemorrhagic cystitis

Answer 5

a

Question 6

6. A 21⁄2-year-old child attending nursery school acquires a mild respiratory infection. Other children in the nursery school have similar illnesses. Which adenovirus types are the most likely causes of the illnesses?
(A) Types 40 and 41
(B) Types 8, 19, and 37
(C) Types 1, 2, 5, and 6
(D) Types 3, 4, and 7
(E) Types 21, 22, 34, and 35

Answer 6

c

Question 7

7. Which adenovirus types are frequent causes of acute respira- tory disease among military recruits?
(A) Types 40 and 41
(B) Types 8, 19, and 37
(C) Types 1, 2, 5, and 6
(D) Types 3, 4, and 7
(E) Types 21, 22, 34, and 35

Answer 7

d

Question 8

8. Which of the following events led to reappearance of acute respiratory disease outbreaks among U.S. military recruits in the late 1990s?
   (A) Emergence of a new virulent strain of adenovirus
   (B) Cessation of adenovirus vaccination program for recruits
   (C) Change in military housing and training conditions for
   recruits
   (D) Cessation of adenovirus antiviral drug therapy program
   for recruits

Answer 8

b

Question 9

9. Your summer research project is to study the viruses that cause gastroenteritis. You recover a virus from a stool sample and notice that the growth medium on the infected cultures is highly acidic. You find that the viral genome is double-stranded DNA. Of the following, which one is the most appropriate con- clusion you could draw?
   (A) There is a high likelihood that the agent is a rotavirus.
   (B) You need to determine the viral serotype to establish
   whether the virus was important in causing the disease.
   (C) The patient should have been treated with the antiviral
   drug amantadine to shorten the duration of symptoms.
   (D) The virus particle would contain a reverse transcriptase
   enzyme.

Answer 9

b

Question 10

10. Which of the following groups of individuals is at the lowest risk of adenovirus disease?
(A) Healthy adults
(B) Young children
(C) Bone marrow transplant recipients
(D) Military recruits
(E) AIDS patients

Answer 10

a

Question 11

11. Adenoviruses can cause eye infections that are highly conta- gious. Which of the following is least likely to be a means of trans- mission during an outbreak of epidemic keratoconjunctivitis?
(A) Swimmingpools
(B) Hand towels
(C) Mosquito bites
(D) Hand-to-eye
(E) Contaminated ophthalmic equipment

Answer 11

c

Question 12

12. There are 57 known sero types of human adenoviruses. Which of the following statements is most accurate?
    (A) Types cannot be distinguished serologically.
    (B) All cause respiratory infections in children.
    (C) Most types replicate well in T lymphocytes.
    (D) Two types can cause gastroenteritis.

Answer 12

d

Question 13

13. Each of the following statements concerning adenoviruses is
    correct except
    (A) Adenoviruses are composed of a double-stranded DNA
    genome and a capsid without an envelope.
    (B) Adenoviruses cause both sore throat and pneumonia.
    (C) Adenoviruses have only one serologic type.
    (D) Adenoviruses are implicated as a cause of tumors in
    animals but not humans.

Answer 13

c

Question 14

14. Which of the following conditions is least likely to be caused by adenoviruses?
A) Conjunctivitis
(B) Pneumonia
(C) Pharyngitis
(D) Glomerulonephritis

Answer 14

d