9.2

Question 1

Identify the three different domains on receptor tyrosine kinase receptors (RTKs)

Answer 1

o Extracellular ligand-binding domain
 binds ligand
o A single transmembrane domain
o Intracellular kinase domain
 activates effector protein

Question 2

Describe the process of dimerization and autophosphorylation of RTKs

Question 3

List the sequence of events during insulin receptor signaling

Question 4

Explain the role of kinase cascades and signal amplification in signal transduction

Answer 4

Kinase cascades cause signal amplification by
activating a greater number of effector molecules
at each step

Question 5

Understand the role of scaffold proteins in kinase cascades

Answer 5

provide greater efficiency of
signaling by brining kinases together