What are 4 adaptations of cells to increase the rate of substance exchange
Thin walls for a short diffusion distance
Large surface area
Good blood supply
Steep concentration gradient
What is the role of Amylase?
Hydrolyses starch to maltose
Why are the disaccharidases and lipase membrane bound?
For a short diffusion distance
Enzymes can be used repeatedly
What is the role of Maltase
Hydrolyses maltose to glucose
What is the role of Lipase
Hydrolyses triglycerides into monoglycerides and 2 fatty acids
What is the role of Sucrase
Hydrolyses sucrose into glucose and fructose
What is the role of Lactase
Hydrolyses lactose into glucose and galactose
Name the three parts of the small intestine in order.
Duodenum
Jejunum
Ileum
What happens in the duodenum of the small intestine
Bile from the liver is released to neutralise stomach acid
Pancreas releases digestive enzymes
What happens in the Jejunum of the small intestine?
Lots of diffusion and facilitated diffusion occur as there is a higher concentration in the lumen than epithelial cells.
What happens in the ileum of the small intestine?
Active transport and co-transport takes place as there is a lower concentration of nutrients in the lumen than epithelial cells.
What are some adaptations of villi to aid absorption?
Very thin membrane so shorter diffusion pathway
Very large surface area
Presence of capillaries maintains a good blood supply
What are the benefits of microvilli?
Give an enormous surface area for absorption
Give more space for channel/carrier proteins
Describe carbohydrate digestion
Salivary amylase enters the mouth and mixes with food, starts hydrolysing starch to maltose
Food enters the stomach, pH is too low for amylase, it denatures
Pancreatic amylase hydrolyses the remaining starch to maltose in the small intestine
Food enters the ileum and disaccharides are hydrolysed by membrane bound disaccharidases
What is the role of endopeptidases
Hydrolyse peptide bonds between amino acids in the central region of a protein molecule, forming a series of peptide molecules
What is the role of exopeptidases?
Hydrolyse peptide bonds on the terminal amino acids of peptide molecules. They progressively release dipeptides and single amino acids
Endo- and exopeptidases are….
Membrane-bound
Describe the absorption of monosaccharides and amino acids, call monosaccharides and amino acids “nutrients”
Sodium ions are actively transported out of ileum epithelial cells into the blood - setting up a sodium ion concentration gradient between the lumen and epithelial cells
Nutrients are co-transported alongside sodium ions from the lumen into epithelial cells
Nutrients move via facilitated diffusion from epithelial cells into the blood
What is the role of bile salts?
Break up lipids into smaller droplets
So lipase can easier digest triglycerides into monoglycerides and fatty acids, which form micelles
Describe the absorption of triglycerides
Micelles are broken down to release fatty acids and monoglycerides
Fatty acids and monoglycerides can diffuse into epithelial cells lining the ileum
Triglycerides reform inside the cells’ endoplasmic reticulum
They are then packaged into chylomicrons in the Golgi body for transport
Chylomicrons are released from epithelial cells via exocytosis into lacteals
Chylomicrons are transported via the lacteals in the lymphatic system to the blood.
What are lacteals?
Lymphatic vessels in the villi
Where do useful amino acids go after absorption?
Sent straight to body cells to be used in the synthesis of proteins
Where do non-useful amino acids go after absorption?
Changed into urea by the liver