Acetaminophen

Question 1

Acetaminophen - trade name

Answer 1

Tylenol

Question 2

Acetaminophen - Classification

Answer 2

Analgesic and Antipyretic

Question 3

Acetaminophen - MOA

Answer 3

MOA
Acts on hypothalamus to reduce fevers (antipyresis)

Can block pain impulse generation

Similar to NSAIDS but little anti-inflam properties

Question 4

Acetaminophen - Onset

Answer 4

Onset - 13-30m
Peak - 30-120m PO
Duration - 3-4hr
1/2 life -
1-3hs (adults)
2-5hrs (child)
4hrs (infants)

Question 5

Acetaminophen - Indications

Answer 5

Mild to moderate pain

Fever

Question 6

Acetaminophen - Contraindications

Answer 6

Severe liver disease
Hypersensitivity

Question 7

Acetaminophen - Precautions

Answer 7

Hepatotoxicity in pt w/ chronic alcohol consumption

may potentiate blood thinners - warfarin and apixaban action

Question 8

Acetaminophen - Side Effects

Answer 8

Angioedema - deep tissue swelling, face, lips, eye, hands and feet

Dizziness
Urticaria
Laryngeal edema
Nausea/vomit
Hepatic toxicity in large doses

Question 9

Acetaminophen - Dose

Answer 9

Dose
Adult - 325-650mg PO q 4-6hrs - max 4000mg/day

Peds - 10-15mg/kg - max 5 doses/day or 2.6g)
ages 2-12 - 12.5mg/kg