What is ADHD?
A persistent pattern of inattention and/or hyperactivity-impulsivity that interferes with functioning and development.
What core abilities are impaired in ADHD?
Attention, impulse control, and executive functioning
By what age must symptoms be present for an ADHD diagnosis?
Before age 12
List key symptoms of inattention in ADHD.
Fails to give attention to details
Difficulty sustaining attention
Does not listen when spoken to
Does not follow through on instructions
Disorganized
Avoids tasks requiring sustained effort
Loses things
Easily distracted
Forgetful
List key hyperactive-impulsive symptoms of ADHD.
Fidgets
Leaves seat
Runs or climbs
Unable to engage in quiet activities
“On the go”
Talks excessively
Blurts out answers
Difficulty waiting turn
Interrupts others
What are the three ADHD subtypes?
ADHD, inattentive type
ADHD, hyperactive-impulsive type
ADHD, combined type
ADHD, inattentive type is characterized by what?
Inattention symptoms dominate; no significant hyperactivity/impulsivity
ADHD, hyperactive-impulsive type is characterized by what?
Hyperactivity/impulsivity dominates; no significant inattention
ADHD, combined type requires what?
Criteria met for both inattention and hyperactivity-impulsivity
Which brain areas are involved in ADHD?
Frontal cortex (executive function, behavior)
Basal ganglia (motor control, learning, emotions)
Reticular activating system (focus, arousal, sleep-wake regulation)
Which neurotransmitters are implicated in ADHD?
Dopamine dysfunction
Norepinephrine dysfunction
Serotonin (secondary role)
ADHD is considered what type of disorder biologically?
A polygenic neurobiological disorder affecting executive functioning
Common mental status exam findings in ADHD?
Restlessness
Inattention
Distractible speech
Overproductive speech
Affective lability
Poor memory and concentration
Common rating scales used to assess ADHD?
Conners’ Parent & Teacher Rating Scales (copyrighted)
Vanderbilt ADHD Diagnostic Scales (public domain)
Why are rating scales important in ADHD?
To establish diagnosis, monitor progress, and track symptom change over time
First-line pharmacologic treatment for ADHD?
Stimulants
Two major stimulant classes used in ADHD?
Amphetamines
Methylphenidate
FDA-approved minimum ages for stimulants?
Amphetamines: age 3+
Methylphenidate: age 6+
What must be assessed before starting stimulants?
Cardiac history (risk of ↑ HR, ↑ BP, MI, stroke)
Common stimulant side effects?
GI upset
Appetite suppression / weight loss
Increased BP and pulse
Headache, dizziness
Irritability
Rare but serious stimulant adverse effects?
Psychosis and growth suppression
When should non-stimulants be considered?
If stimulants are ineffective or cause intolerable side effects (e.g., tics)
FDA-approved non-stimulants for ADHD?
Atomoxetine (Strattera) – age 6+
Guanfacine (Intuniv) – ages 6–17
Clonidine (Kapvay) – ages 6–17
Qulbree ~ ages 6-17
Which antidepressants may be used off-label for ADHD?
Desipramine, venlafaxine, bupropion