Adverse effects

Question 1

the sexual side effects caused by SSRI are related to which receptors

Answer 1

5HT-2 receptors

Question 2

how does topiramate work

Answer 2

inhibits release of glutamate and potentiates GABA

Question 3

side effects of topiramate

Answer 3

appetite suppression and weight loss

Question 4

increased risk of dyskinesias

Answer 4

typical antipsychotics, patients with organic brain damage, females, patients with affective disorders, older patients

Question 5

closed angle glaucoma which medication is contraindicated

Answer 5

Paroxetine

Question 6

Tricyclic with highest antihistaminergic activity

Answer 6

dose-in

Question 7

antipsychotic with low risk of weight gain

Answer 7

aripirazole, haloperidol, amisulpride

Question 8

what happens to plasma levels of tricyclics and antipsychotics if co-administered

Answer 8

TCAs potentiate effect of alcohol, hypnotics, anxiolytics and antipsychotics

Question 9

Bupropion side effects

Answer 9

can cause weight loss

Question 10

MAOI induced hypertensive crisis should be treated with?

Answer 10

alpha-adrenergic antagonists e.g. phentolamine or chlorpromazine

Question 11

muscle spasm in neck

Answer 11

acute dystonia

Question 12

nephrolithiasis associated with

Answer 12

topiramate

Question 13

most common and early side effect of lithium

Answer 13

fine tremor

Question 14

maternal mental health problems and lithium

Answer 14

maternal mental health problems in general may increase risk of Ebstein anomaly

Question 15

lithium induced hypothyroidism is most common in

Answer 15

young females

Question 16

anxious and constantly crossing and uncrossing legs

Answer 16

akathisia

Question 17

tardive dystonias occur

Answer 17

months to years after antipsychotic treatments

Question 18

avoid what in weight gain

Answer 18

tricyclics
paroxetine and citalopram may cause weight gain

Question 19

what percentage of patients on antipsychotics develop NMS

Answer 19

2-3%

Question 20

rare with rivastigmine

Answer 20

constipation

Question 21

Thioridazine risk

Answer 21

QTc prolongation and sudden cardiac death

Question 22

acetylcholinesterase inhibitors

Answer 22

cause urinary retention

Question 23

antidotes to reboxetines anticholinerfi aside effects

Answer 23

doxazosin

Question 24

fatal agranulocytosis clozapine risk

Answer 24

1/4250

Question 25

clozapine and olanzapine should have serum lipids measured

Answer 25

every 3 months for the first year of treatment

Question 26

Weight gain is caused by

Answer 26

5-HT2-C antagonism H! antagonistm hyperprolactinaemia increased serum leptin

Question 27

not a dose dependent effect when using clozapine

Answer 27

agranulocytosis

Question 28

hyperprolactinaemia can cause

Answer 28

galactorrhoea reductions in bone mineral density amenorrhoea gynaecomastia

Question 29

Contraindicated in a MAO inhibitor

Answer 29

Meperidine

Question 30

Olanzapine discontinuation rate in CATIE

Answer 30

64%

Question 31

clozapine induced hyper salivation treatment

Answer 31

amitriptyline benzatropine +terazosin trihexyphenidyl hyoscine pirenzine

Question 32

Trazadone is associated with

Answer 32

priapism

Question 33

which benzodiazepine is most toxic and fatal in overdose

Answer 33

alprazolam

Question 34

which antibiotic can cause serotonin syndrome if combined with SSRIs

Answer 34

Linezolid

Question 35

dystonia what should be prescribed

Answer 35

IM anticholinergics e.g. procyclidine 5mg, benzatropine 2mg

Question 36

Lamotrigine

Answer 36

can cause Steven Johnsons syndrome

Question 37

Botulinum toxin can have a role in treatment of

Answer 37

tardive dystonia

Question 38

Venlafaxine side effect controlled by terazosin

Answer 38

sweating

Question 39

what can be used to control lithium-induced polyuria without causing lithium toxicity

Answer 39

amiloride