Hiyield 2 > Basic pharmacology > Flashcards

Basic pharmacology Flashcards

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1
Q

Zimeldine belongs to which class

A

SSRI
- zimeldine is first SSRI to reach the market

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2
Q

reversible MAOI example

A

moclobemide

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3
Q

lofexidine is a

A

alpha 2 adrenergic agonist

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4
Q

which antidepressant has two enantiomers

A

Citalopram - R and S
Escitalopram - S enantiomer

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5
Q

buspirone belongs to the chemical class

A

azaspirone

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6
Q

what is associated with valproate in mania

A

Boweden (1994)

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7
Q

paliperidone is which class of drug

A

benzisoxazoles (active metabolite of risperidone)

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8
Q

SNRI example

A
  • duloxetine
  • venlafaxine
  • desvenlafaxine
  • milnacipran
  • levomilnacipran
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9
Q

first class of antidepressant to be produced

A

MAO inhibitor - iproniazid

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10
Q

zopiclone which class

A

cyclopyrrolone

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11
Q

zolpidem class

A

imidazopyridine

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12
Q

zaleplon class?

A

pyrazopyrimide

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13
Q

standardised difference in effectiveness

A

difference in the effect of treatment in active treatment group compared to the placebo group

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13
Q

treatment resistant depression

A

venlafaxine and mirtazapine

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14
Q

bupropion mechanism of action

A

noradrenaline and dopamine reuptake inhibitor

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15
Q

clozapine’s special efficacy in treatment resistant schizophrenia

A

Kane

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16
Q

valproate and lamotrigine

A

bowden

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17
Q

clozapine

A

kane

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18
Q

Reversible MAOI

A

moclobemide

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19
Q

lofexidine class

A

alpha 2 agonist (used for opioid withdrawal)

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20
Q

buspirone chemical class

A

azaspirone

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21
Q

valproate and acute mania

A

bowden

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22
Q

paliperidone belongs to class

A

benzixasazoles

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23
Q

duloxetine

A

an inhibitor of noradrenaline and serotonin reuptake

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24
First antidepressant to be produced
iproniazid
25
zopiclone belongs to which chemical class
cyclopyrrolones
26
zolpidem belongs to
imidazopyridine
27
zaleplon belongs to
pyrazopyrimide
28
tranquillising drug (first)
chlorpromazine under delay and denser
29
Treatment resistant depression
VEnlafaxine and mirtazapine
30
standardised difference in effectiveness
between the active treatment group compared to the placebo group after taking into account the variation in treatment effect
31
bupropion mechanism of action?
noradrenaline and dopamine re-uptake inhibitor
32
proof of clozapine's success in treatment resistant schizophrenia
Kane
33
alprazolam is which class
benzodiazepines
34
chlorpromazine is what?
a major tranquilliser
35
lithium is associated with
cade
36
droperidol is which class of drug
butyrophenones
37
other examples of butyrophenones
haloperidol, droperidol, benperidol
38
butyrophenone derivative?
haloperidol, droperidol and penperidol
39
hormone used in treatment of depression
thyroid hormone
40
increase seizure risk in depression
bupropion - aminoketone increases risk of seizures
41
Rivastigmine
reversible non-competitive inhibitor of acetylcholinesterase
42
prior therapeutic experiences drive what?
the nocebo effect
43
which is a substituted benzamide used as an antipsychotic
amisulpride
44
risperidone's metabolite
paliperidone
45
Flupenthixol belongs to the chemical class of
thioxanthene
46
zuclopenthixol
thioxanthene
47
active placebo
placebo has some activity inherently
48
buspirone is what
5-HT1A partial agonist - classified as an azapirone (or azaspirone
49
cyproterone acetate is what
testosterone antagonist
50
opioid have a role to play in?
the placebo response
51
before approval of drug molecule, mutagenicity, carcinogenicity and organ system toxicity is studied at which phase?
preclinical animal phase
52
applies to the chemical structure of buspirone?
azaspirone-decanedione
53
duloxetine and milnacipran is classified as
serotonin and noradrenergic reuptake inhibitors
54
which psychotropics can cause sudden death
thioridazine
55
placebo effect is not mediated via the
nocebo response
56
which psychotropic agent has same pharmacokinetic properties in Asians and white europeans
Lithium
57
benzisoxazole derivative
risperidone
58
example of thienbenzodiazepine
olanzapine
59
Acamprosate
synthetic taurine analogue
60
NMDA antagonist
memantine
61
Reserpine
rauwolfia serpentina
62
secondary amine example
amoxapine
63
potential advancement in dementia
drugs acting on intracellular secretes enzymes
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