Alpha-2 Agonists

Question 1

Clonidine (g)

Answer 1

Catapres, Nexiclon XR, Kapvay (b)

Question 1

Guanfacine (g)

Answer 1

Intuniv, Tenex (b)

Question 2

MOA

Answer 2

stimulates alpha receptors in CNS and activates inhibitory neurons which results in neg feedback inhibition and ultimately reduction in BP.

Question 3

common adverse effects

Answer 3

dry mouth/dry eyes
dizziness
headache

Question 4

rare adverse effects

Answer 4

neurologic disturbances including hallucinations and confusion (guanfacine)

Question 5

counseling pts.

Answer 5

may take with food if GI upset occurs.
do not take the ER tables with high fat meal (guanfacine)

Question 6

clinical pearls

Answer 6

abrupt discontinuation can result in rebound hypertension (clonidine).
patch used more frequently to decrease ADEs.
guanfacine ER also used in ADD/ADHD.