TZD

Question 1

Pioglitazone (g)

Answer 1

Actos (b)

Question 2

MOA

Answer 2

improves insulin sensitivity in muscle and liver; peroxisome-proliferator-activated receptor gamma agonist

Question 3

common adverse effects

Answer 3

edema (swelling)
weight gain
bone fractures

Question 4

rare adverse effects

Answer 4

bladder cancer

Question 5

counseling pts.

Answer 5

monitor for signs of HF.
may take 6-8 weeks to see full effect.

Question 6

clinical pearls

Answer 6

BBW: avoid in pts with HF.
avoid in elderly pts with osteoporosis.