Thiazides

Question 1

Hydrochlorothiazide (generic)

Answer 1

Microzide (brand)

Question 1

Chlorthalidone (generic)

Answer 1

Thalitone (brand)

Question 2

Metolazone (generic)

Answer 2

Zaroxolyn (brand)

Question 3

MOA

Answer 3

inhibit sodium reabsorption in distal convoluted tubule, causing increased excretion of Na and Water (lower BP)

Question 4

common adverse effects

Answer 4

dizziness
hypotension
headache
electrolyte loss/imbalance

Question 5

counseling pts.

Answer 5

take daily, do not double up on doses.
may take with/without food.

Question 6

clinical pearls

Answer 6

similar structure to sulfa meds (possible allergy).
chlorthalidone has longer half-life and better CVD protection.
not recommended in pts with severe kidney disease.